不同浓度四君子汤对尾部悬吊大鼠比目鱼肌肌萎缩的影响

发布时间：2018-03-23 19:55

  本文选题：模拟失重　切入点：比目鱼肌　出处：《航天医学与医学工程》2009年01期

【摘要】：目的观察不同浓度四君子汤对尾部悬吊大鼠比目鱼肌肌萎缩的影响。方法尾部悬吊法建立模拟失重模型,30只Sprague-Dawley大鼠随机分为5组,同步饲养组(CON)、尾吊组(HLU-W)、尾吊+四君子汤高(HLU-H)、中(HLU-M)、低(HLU-L)浓度组,每组6只。用免疫组织化学法观察药物对比目鱼肌肌球蛋白重链(MHC)的影响。结果与尾吊组相比,四君子汤高、中浓度组使比目鱼肌湿重分别增加了33.11%和37.57%,与同步饲养组亦无显著性差异;四君子汤高、中、低浓度组使比目鱼肌Ⅰ型肌纤维比例增加了34.04%～54.90%,Ⅰ型肌横截面积增加了8.50%～36.86%,且中浓度组与同步饲养组相比亦无显著性差异。结论3种浓度的四君子汤对模拟失重引起的比目鱼肌肌萎缩有显著的对抗作用,且中浓度四君子汤的效果优于高、低浓度。
[Abstract]:Objective to observe the effect of Sijunzi decoction of different concentration on muscle atrophy of soleus muscle in tail-suspended rats. Methods Thirty Sprague-Dawley rats with simulated weightlessness were randomly divided into 5 groups. The effect of drugs on myosin heavy chain (MHCC) of soleus muscle was observed by immunohistochemical method. The results showed that Sijunzi decoction was higher than that of tail suspension group. The wet weight of soleus muscle was increased by 33.11% and 37.57% respectively in the medium concentration group, and there was no significant difference between the two groups. In the low concentration group, the proportion of myofiber of soleus muscle type I increased by 34.04 and 54.90, and the cross sectional area of type 鈪，

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