开放性犬颅脑爆震伤合并海水浸泡的早期脑组织病理学改变观察

发布时间：2018-03-29 10:23

本文选题：颅脑爆震伤　切入点：海水　出处：《解放军医学杂志》2010年07期

【摘要】：目的观察并分析开放性犬颅脑爆震伤合并海水浸泡伤后的早期脑组织病理学改变。方法 30只健康成年犬随机分为单纯颅脑伤组和海水浸泡颅脑伤组,每组15只。以颅中线向左(或右)1cm、眶上缘向上1cm交界处为爆震中心,将1gTNT当量的点爆震源放置于距离犬头部皮肤3.5mm处引爆致伤。随后将装有福建沿海区域海水的输液器置入海水浸泡颅脑伤组动物的颅部伤道中,以500ml/h的速度对伤口进行滴注,而单纯颅脑伤组不进行海水滴注。分别观察致伤后3、5、8h两组动物局部伤道、颅内血肿、脑水肿等的变化及发展情况。结果在颅脑爆震伤后3、5、8h,海水浸泡颅脑伤组脑水肿的严重程度均明显轻于单纯颅脑伤组;两组均可见明显的骨折、硬膜外出血、硬膜下出血、脑挫裂伤、颅内点状出血及爆震所致的其他部位损伤。结论海水对于爆震伤早期后脑组织的变性具有延缓和减轻作用,这可能与海水的高渗因素相关。
[Abstract]:Objective to observe and analyze the early pathological changes of brain tissue in open dogs after craniocerebral explosive injury combined with seawater immersion injury. Methods Thirty healthy adult dogs were randomly divided into two groups: pure craniocerebral injury group and seawater immersion craniocerebral injury group. 15 rats in each group. The center of detonation was located at the left (or right) of the midline of the skull, with the upper orbital margin upward at the junction of 1cm. The point detonation source of 1gTNT equivalent was placed in the 3.5mm of the dog's head skin to detonate the wound. Then the infusion device with seawater in the coastal area of Fujian was placed in the cranial wound canal of the animals in the group of brain injury immersed in seawater, and the wound was dripped at the speed of 500ml/h. However, no seawater drip was used in the simple craniocerebral injury group, and the local wound tract and intracranial hematoma were observed in the two groups at 3h and 5h after injury, respectively. Results the severity of brain edema in the seawater immersion group was significantly less than that in the pure brain injury group, and obvious fracture, epidural hemorrhage and subdural hemorrhage were observed in both groups. Conclusion seawater can delay and alleviate the degeneration of brain tissue in the early stage of blast injury, which may be related to the hyperosmotic factors of seawater.
【作者单位】：第四军医大学唐都医院神经外科;西北核技术研究所;
【分类号】：R82

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