硫芥中毒复合腹部穿透伤的初步实验研究

发布时间：2018-04-02 11:39

本文选题：硫芥　切入点：火器伤　出处：《中国药理学与毒理学杂志》2003年04期

【摘要】：目的　观察硫芥中毒复合枪弹伤伤情 ,以了解硫芥中毒复合伤伤情特点 ,为临床救治提供帮助。方法　实验兔分中毒复合火器伤组及假手术组。中毒复合伤组 :兔正中切 1～ 2cm小口入腹 ,提起胃窦部缝扎固定于腹壁 ,固定于枪击架上 ,左侧腹部硫芥染毒 5min后 ,5 4式手枪距腹部 2 0cm枪击 ,立即进行中毒急救及手术救治。假手术组 :兔以生理盐水替代硫芥中毒 ,剖腹探查 (进腹 ,不做胃手术 )时间同实验组。 2 4h后观察存活率。结果　假手术组及单纯硫芥中毒组 2 4h死亡率均为 0 %。中毒复合枪伤的手术急救组 2 4h死亡率为 2 5 % ,未进行手术急救的死亡率为 10 0 %。死亡兔为腹腔内出血较多及创伤较重有关。结论　硫芥中毒复合火器伤的救治应在局部消毒、清创的同时以首先抢救火器伤情为主。
[Abstract]:Objective to observe the injuries caused by sulfur mustard poisoning combined with gunshot wounds and to understand the characteristics of compound injuries caused by sulfur mustard poisoning. Methods the experimental rabbits were divided into two groups: the group of poisoning combined with firearm injury and the group of sham operation. The compound injury group was divided into two groups: the rabbits were cut 1 ~ 2cm into the abdomen, the antrum was lifted and fixed on the abdominal wall, and fixed on the gunshot frame. After the left abdominal sulfur mustard was poisoned with 5min, the 54-type pistol was shot at 2 0cm from the abdomen, and immediate emergency treatment and surgical treatment were performed. Sham operation group: rabbits were poisoned by normal saline instead of sulfur mustard poisoning, and explored by laparotomy. The survival rate was observed after 24 hours. Results the mortality of sham operation group and simple sulfur mustard poisoning group was 0. The 24 h mortality rate of the first aid group with compound gunshot injury was 25%. The mortality rate of non-operative first aid was 100. The main cause of death was intraperitoneal hemorrhage and severe trauma in rabbits. Conclusion the treatment of sulfur mustard poisoning combined with firearm injury should be local disinfection, debridement is the first rescue of firearm injuries.
【作者单位】：解放军第101医院外科解放军第101医院外科第二军医大学海医系第二军医大学海医系军事医学科学院毒物药物研究所解放军307医院军事医学科学院毒物药物研究所
【分类号】：R82

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