尾吊复合隔离导致的大鼠抑郁样行为研究

发布时间：2018-04-08 12:19

本文选题：尾吊　切入点：隔离　出处：《航天医学与医学工程》2017年06期

【摘要】：目的研究2周的尾吊复合隔离环境所导致的大鼠抑郁样行为。方法 24只雄性SD大鼠随机平均分为3组:对照(Con)、尾吊(tail suspension,TS)、尾吊复合隔离(tail suspension combined with isolation,TS+I)。造模前后检测摄食量和体重变化,造模结束后依次进行空场、新奇事物探索、强迫游泳实验。结果 TS和TS+I组大鼠体重和摄食量低于对照组,且TS+I组最低。TS和TS+I组大鼠的主动性活动显著少于对照组,且TS+I组大鼠最少。TS和TS+I组大鼠探索潜伏期变长,且探究行为减少,其中TS+I组大鼠表现最差。TS和TS+I组大鼠的攀爬次数少于对照组,TS+I组大鼠不动时间最长。结论 2周的尾吊复合隔离环境导致的抑郁样行为比单一尾吊更为严重,此模型可用于航天抑郁发病机制研究及对抗药物开发。
[Abstract]:Objective to study the depressive behavior of rats after 2 weeks of tail suspension combined isolation.Methods Twenty-four male Sprague-Dawley rats were randomly divided into three groups: control group, tail suspension suspension combined with isolation group.The changes of food intake and body weight were measured before and after modeling. After the model was finished, the empty field, novelty exploration and forced swimming experiment were carried out successively.Results the body weight and food intake in TS and TS I groups were significantly lower than those in control group, and the active activity of TS I group was significantly lower than that of control group, and the latency of exploration in TS I group and TS I group was longer than that in TS I group.The number of climbing in TS I group and TS I group was less than that in control group (TS I group), and the immobility time of TS I group was longer than that of control group (P < 0.05).Conclusion the depressive behavior caused by combined tail suspension isolation for 2 weeks is more serious than that in single tail suspension. This model can be used to study the pathogenesis of space depression and to develop antidepressant drugs.
【作者单位】：西北工业大学生命学院;中国航天员科研训练中心航天医学基础与应用国家重点实验室;
【基金】：中国航天医学工程预先研究项目(2015SY54A0501) 航天医学基础与应用国家重点实验室自主研究项目(SMFA15B01)
【分类号】：R85

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