防晕船口服液对晕船患者心率变异性的影响

发布时间：2018-04-16 18:24

本文选题：晕动病 + 生姜　；参考：《解放军医学杂志》2006年05期

【摘要】：目的观察在海上口服防晕船口服液对晕船高敏者心率变异性的影响。方法在登陆艇上进行双盲对照试验,随机选取10名晕船不敏感者作为对照组,40名晕船高敏者分为安慰组和试验组,分别于开船前半小时服用安慰剂(对照组、安慰组)和防晕船口服液(试验组),记录受试者4h动态心电图,应用心率变异时域、频域分析方法评价自主神经功能状态,并记录受试者出现的晕船症状。结果防晕船口服液具有良好的预防晕船作用,安慰组抗晕船作用很小,有效率仅20%,而试验组中有7例显效,总有效率达85%,明显优于安慰组(P0.01)。安慰组和试验组的时域指标全部窦性心搏R-R间期的标准差(SDNN)、相邻R-R间期差值的均方根值(rMSSD)、相邻RR间期大于50ms占总心动周期数的百分比(PNN50)、每5min时段平均R-R间期的标准差(SDANN)、每5min时段R-R间期标准差的平均值(SDNNindex)和频域指标总功率(TP)、高频功率(HF)均显著高于对照组,其中上述指标在试验组均显著低于安慰组;而极低频功率(VLF)在三组间差异无显著性。结论防晕船口服液具有明显的预防晕船作用,其抗运动病机制可能与降低过高的迷走神经兴奋性有关。
[Abstract]:Objective to observe the effect of oral antiseasickness oral liquid on heart rate variability in patients with seasickness Gao Min.Methods A double-blind controlled trial was conducted on board the landing boat. Ten seasickness insensitive persons were randomly selected as the control group. 40 patients with seasickness were divided into comfort group and test group. They were treated with placebo half an hour before sailing (control group).Comfort group) and anti-seasickness oral liquid (test group, recorded 4 h dynamic electrocardiogram, heart rate variability time domain, frequency domain analysis method to evaluate the autonomic nervous function, and recorded the symptoms of seasickness.Results the anti-seasickness oral liquid had a good effect on preventing seasickness. In the comfort group, the anti-seasickness effect was very small, and the effective rate was only 20. In the test group, there were 7 cases with remarkable effect, the total effective rate was 85%, which was obviously better than that of the comfort group (P 0.01).In comfort group and trial group, the standard deviation of R-R interval of sinus beats was determined by SDNN, the root mean square value of RR-R interval of adjacent R-R interval was more than that of 50ms, and the mean R-R interval per 5min period was higher than that of PNN50, and the standard deviation of R-R interval per 5min period was higher than that of PNN50.The average value of R-R interval standard deviation per 5min period and the total power in frequency domain were significantly higher than those in the control group, and the mean value of R-R interval standard deviation per 5min period was significantly higher than that of the control group, and the total power and high frequency power in the frequency domain were significantly higher than those in the control group.The above indexes were significantly lower in the trial group than in the comfort group, but the VLFs of the very low frequency power were not significantly different among the three groups.Conclusion Anti-seasickness oral liquid has obvious effect on preventing seasickness, and its mechanism of anti-motion sickness may be related to the reduction of excitability of vagus nerve.
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【分类号】：R83

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