无创尾吊大鼠心血管功能监测新方法

发布时间：2018-04-25 09:05

本文选题：植入式遥测 + 心血管参数　；参考：《第四军医大学学报》2009年22期

【摘要】：目的:运用植入式遥测系统建立一种在体的实时监测无创尾部悬吊大鼠心血管生理参数模型.方法:将SD雄性大鼠随机分为对照组,尾吊组,每组5只.手术植入遥测子后记录尾吊前后各组大鼠血压(BP)、心率(HR)、心电图(ECG)变化.结果:所有大鼠在手术14d后完全恢复,体质量显著增加;尾吊组大鼠在尾吊0～5min时BP,HR值逐渐上升,随后逐渐下降,5.5h后维持稳定.其中BP值高于尾吊前及对照组,HR未出现类似状况.RR间期在尾吊0～5min下降,之后逐渐升高至尾吊前水平,对照组大鼠各项参数值无显著变化.结论:植入式遥测系统适用于监测尾吊大鼠心血管生理参数变化,为进一步研究失重引起的心血管功能变化提供了可靠的技术方法和实验依据.
[Abstract]:Aim: to establish a real-time monitoring model of cardiovascular physiological parameters of non-invasive tail suspension rats by implantable telemetering system. Methods: SD male rats were randomly divided into control group and tail suspension group with 5 rats in each group. The changes of blood pressure, heart rate, HRG and ECG were recorded before and after tail suspension. Results: all the rats recovered completely and the body mass increased significantly after 14 days of operation, and the BPHR value of tail suspension group increased gradually during 0~5min, then decreased gradually and remained stable after 5.5 hours. The BP value was higher than that before tail suspension and the HR of control group had no similar condition. RR interval decreased gradually after tail suspension, and then increased to the level before tail suspension. The parameters of control group had no significant change. Conclusion: the implantable telemetry system is suitable for monitoring the changes of cardiovascular physiological parameters in tail suspension rats and provides a reliable technical method and experimental basis for further study of cardiovascular function changes caused by weightlessness.
【作者单位】：西北工业大学生命科学院空间生物实验模拟技术国防重点学科实验室;第四军医大学药学系药理学教研室;
【分类号】：R85

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