海拔高度对武警战士脂质过氧化与抗氧化系统的影响

发布时间：2018-05-07 09:48

本文选题：海拔 + 脂质过氧化与抗氧化系统　；参考：《环境与职业医学》2004年01期

【摘要】：[目的]探讨海拔高度对机体脂质过氧化与抗氧化系统的影响。[方法]选择144名武警战士作为调查对象 ,其中高原组78名 ,平原组66名。采用南京建成生物研究所试剂盒检测血浆或血清中一氧化氮 (NO)、一氧化氮合酶(NOS)、活性氧 (ROS)、丙二醛 (MDA)、谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH_Px)、谷胱甘肽S_转移酶 (GSH_ST)、超氧化物歧化酶 (SOD)的含量或活力。[结果]与平原组相比 ,高原组GSH含量下降 ,GSH_Px、GSH_ST、SOD含量或活力升高 ,差异具有显著性(P0.05) ;NO、NOS、ROS、MDA差异无显著性(P0.05)。GSH含量的多少是影响机体抗氧化能力大小的重要因素,GSH含量的降低 ,提示机体清除氧自由基的能力已有所下降 ;GSH_Px、GSH_ST、SOD含量或活力升高可能是机体代偿性反应的结果。[结论]高海拔生活环境可能导致机体抗氧化能力下降
[Abstract]:[objective] to study the effect of altitude on lipid peroxidation and anti-oxidation system. [methods] 144 soldiers of armed police were selected as subjects, including 78 in plateau group and 66 in plain group. Nitrous oxide (no), nitric oxide synthase (NOS), reactive oxygen species (Ros), malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSHPxX), glutathione (GSH) S _ T (GSHST) in plasma or serum were detected by Nanjing Institute of Biological Research. The content or activity of superoxide dismutase (SOD). [results] compared with the plain group, the GSH content in the high altitude group decreased and the SOD content or the activity of the GSH-PxSS-STH increased, and the difference was significant (P0.05). There was no significant difference in the content of GSH between the two groups. The decrease of the GSH content was an important factor affecting the antioxidant capacity of the body, and there was no significant difference in the content of GSH between the high altitude group and the plain group, and there was no significant difference in the content of GSH between the two groups. The results suggest that the ability of scavenging oxygen free radical has been decreased. The increase of SOD content or activity in GSHPxS / GSHSTT may be the result of compensatory reaction. [conclusion] living environment at high altitude may lead to decrease of antioxidant capacity.
【作者单位】：武警四川总队成都医院检验科华中科技大学同济医学院职业医学研究所武警四川总队成都医院检验科华中科技大学同济医学院职业医学研究所武警四川总队成都医院检验科武警四川总队成都医院检验科武警四川总队成都医院检验科武警四川总队成都医院检验科华中科技大学同济医学院职业医学研究所
【基金】：国家自然科学基金资助 (编号:30071652)
【分类号】：R82

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