一种复方制剂对尾部悬吊大鼠比目鱼肌mATP酶活性升高及肌萎缩的对抗效应观察

发布时间：2018-05-16 17:31

  本文选题：模拟失重 + 比目鱼肌　； 参考：《中国应用生理学杂志》2008年03期

【摘要】：目的:探讨一种中药复方制剂RC对模拟失重条件下大鼠比目鱼肌(SOL)的mATP酶活性及肌萎缩的影响。方法:尾部悬吊法建立大鼠模拟失重模型,测量比目鱼肌的湿重体重比(mg/g),以Ca2+-ATPase法测定比目鱼肌中mATP酶活性,计算Ⅰ型和Ⅱ型肌纤维的比例,测定比目鱼肌中Ⅰ型和Ⅱ型肌纤维的横截面积(CSA)。结果:与吊尾+溶媒灌胃组相比,吊尾14天后,吊尾+RC灌胃组的湿重体重比增加了33.33%(P0.01);比目鱼肌中Ⅰ型和Ⅱ型肌纤维CSA均显著增加(143.03%,P0.01;83.25%,P0.01);比目鱼肌中Ⅰ型肌纤维比例明显升高,Ⅱ型肌纤维比例明显降低(P0.01)。结论:复方制剂RC对模拟失重条件下大鼠比目鱼肌mATP酶活性的升高与模拟失重引起的肌萎缩有显著的对抗作用。
[Abstract]:Aim: to investigate the effects of RC, a compound preparation of traditional Chinese medicine, on the activity of mATP and muscle atrophy of soleus muscle under simulated weightlessness in rats. Methods: the rat model of simulated weightlessness was established by tail suspension. The wet weight / body weight ratio (WWR) of soleus muscle was measured. The activity of mATP enzyme in soleus muscle was measured by Ca2 -ATPase method, and the ratio of type 鈪，

本文编号：1897774