胸部开放伤后海水和淡水浸泡对肺损伤的作用比较

发布时间：2018-06-01 19:36

本文选题：急性肺损伤 + 淡水　；参考：《第三军医大学学报》2009年21期

【摘要】：目的比较胸部开放伤后胸腔海水与淡水浸泡对肺损伤的作用。方法24只实验犬致胸部开放伤后分成对照组、海水组和淡水组。海水组和淡水组伤后10min内经伤口分别灌入海水和淡水;观察胸部开放伤后0、2、4、6、8h的生命体征,测渗透压、血浆炎症因子变化。伤后8h取肺组织观察病理学和炎症因子变化。结果肺泡通透指数:海水组较淡水组明显升高(P0.05),淡水组与对照组比较无统计学差异(P0.05);IL-1β、IL-8:海水组较淡水组升高(P0.05),淡水组较对照组升高(P0.05);血管性血友病因子(von Willnbrang factor,vWf):海水组较淡水组、对照组升高(P0.05),淡水组较对照组无差异。相关分析显示:血浆渗透压与肺泡通透性指数、炎症因子IL-1β、IL-8正相关(P0.05)。结论海水较淡水对开放伤后肺组织的损伤程度更严重,可能与海水高渗加重肺血管通透性和过度炎症反应有关。
[Abstract]:Objective to compare the effects of seawater and fresh water immersion on lung injury after open chest injury. Methods 24 dogs with open chest injury were divided into control group, seawater group and fresh water group. In seawater group and fresh water group, 10min were perfused into seawater and fresh water respectively, the vital signs, osmotic pressure and plasma inflammatory factors were observed for 8 h after open chest injury. Lung tissues were taken 8 hours after injury to observe the changes of pathological and inflammatory factors. Results the alveolar permeability index in seawater group was significantly higher than that in fresh water group, but there was no significant difference between fresh water group and control group. The levels of IL-1 尾 IL-8 in seawater group were higher than that in fresh water group, and that in fresh water group was higher than that in fresh water group. There was no difference between fresh water group and control group. Correlation analysis showed that plasma osmotic pressure was positively correlated with alveolar permeability index and inflammatory factor IL-1 尾 -IL-8 (P 0.05). Conclusion the degree of lung injury in seawater is more serious than that in fresh water, which may be related to hyperosmotic pulmonary vascular permeability and excessive inflammation.
【作者单位】：军事医学科学院研究生队;海军总医院呼吸科;解放军总医院胸外科;
【基金】：海军后勤科研计划课题(2004-3304)~~
【分类号】：R83

【参考文献】