高分子药物学的研究进展与期盼

  本文关键词：高分子药物学的研究进展与期盼，，由笔耕文化传播整理发布。

全文: (4097 KB)   (1 KB) 
输出: BibTeX | EndNote (RIS)      

摘要 自从20世纪70年代提出高分子前药的概念以来,伴随着纳米技术的发展,"高分子药物学"作为高分子科学和材料学、纳米科学、药物学、临床医学、分析科学的交叉学科,正在悄然形成.本文综述了近年高分子药物在药物化学、制剂学、药效学等方面所取得的进展,概述了高分子药物的药理学和药代动力学与小分子药物的区别与联系,指出了高分子药物药效学、药理学和药代动力学研究中的难题和瓶颈,特别是高分子药物可能存在的"三种状态"及从"纳米颗粒药"到"单个高分子药"再到"小分子药"的转变,分析了高分子药输送过程中存在的多重屏障如毛细血管壁、细胞外基质和细胞壁等,阐述了高分子药物的"生理靶向"和"EPR"效应的竞争,指出了高分子药在靶向输送和逆转耐药方面的优势,强调了发展相关分析方法的必要性,期盼高分子科学家与药物学家进行真诚有效的合作,大力促进我国高分子药物学和高分子药物产业的创新和发展.

服务

E-mail Alert

RSS

收稿日期: 2013-01-04     

基金资助:

国家自然科学基金项目(基金号21004062, 51103148)和国家重点基础研究发展计划(973计划,项目号 2009CB930102).

通讯作者: 景遐斌   

引用本文:   

胡秀丽, 谢志刚, 黄宇彬, 景遐斌. 高分子药物学的研究进展与期盼[J]. Acta Polymerica Sinica, 2013, (6): 733-749.
Xiu-li Hu, Zhi-gang Xie, Yu-bin Huang, Xia-bin Jing. THE PROGRESS AND EXPECTATION OF POLYMER PHARMACY. Acta Polymerica Sinica, 2013, 0(6): 733-749.

链接本文:  

     或     

1 Zeuzem S, Feinman S V,Rasenack J,Heathcote E J,Lai M Y,Gane E.New Engl J Med,2000,343(23):1666~1672
2 Ringsdorf H.J Polym Sci PartC-Polym Symposium,1975,(51):135~153
3 Gros L,Ringsdorf H,Schupp H.Angew Chem Int Edit,1981,20(4):305~325
4 Hu X,Jing X.Expert Opin Drug Del,2009,6(10):1079~1090
5 Pasut G,Veronese F M.Adv Drug Del Rev,2009,61(13):1177~1188
6 Reddy K R,Modi M W,Pedder S.Adv Drug Del Rev,2002,54(4):571~586
7 Veronese F M,Mero A.Biodrugs,2008,22(5):315~329
8 Li C,Wallace S.Adv Drug Del Rev,2008,60(8):886~898
9 Greco F,Vicent M J.FrontBiosci-Landmark,2008,13:2744~2756
10 Lammers T,Ulbrich K.Adv Drug Del Rev,2010,62(2):119~121
11 Ulbrich K,Subr V.Adv Drug Del Rev,2010,62(2):150~166
12 Satchi R,Connors TA,Duncan R.Brit J Cancer,2001,85(7):1070~1076
13 Satchi-Fainaro R,Hailu H,Davies J W,Summerford C,Duncan R.Bioconjugate Chem,2003,14(4):797~804
14 McNamara MV,Doroshow JH,Dupont J,Spriggs D,Eastham E,Pezzulli S.J Clin Oncol,2004,22(14):145S~S
15 Li C,Yu D F,Newman R A,Cabral F,Stephens L C,Hunter N,Milas L,Wallace S.Cancer Res,1998,58(11):2404~2409
16 Greenwald R B.J Control Release,2001,74(1-3):159~171
17 Greenwald R B,Conover C D,Choe Y H.Crit Rev Ther Drug,2000,17(2):101~161
18 Greenwald R B,Gilbert C W,Pendri A,Conover C D,Xia J,Martinez A.J Med Chem,1996,39(2):424~431
19 Pendri A,Conover C D,Greenwald R B.Anti-Cancer Drug,1998,13(5):387~395
20 Agnihotri S A,Mallikarjuna N N,Aminabhavi T M.J Control Release 2004,100(1):5~28
21 Kumar M.Reac Funct Polym,2000,46(1):1~27
22 Roy K,Mao H Q,Huang S K,Leong K W.Nat Med,1999,5(4):387~391
23 SugaharaS-i,Kajiki M,Kuriyama H,Kobayashi T R.J Control Release,2007,117(1):40~50
24 Sugahara S,Kajiki M,Kuriyama H,Kobayashi T R.Bio Pharm Bull,2002,25(5):632~641
25 Kim D W,Kim S Y,Kim H K,Kim S W,Shin S W,Kim J S.Ann Oncol,2007,18(12):2009~2014
26 Lee K S,Chung H C,Im S A,Park Y H,Kim C S,KimS-B,Rha S Y,Lee M Y,Ro,J.Breast Cancer Res Tr,2008,108(2):241~250
27 Kim T Y,Kim D W,Chung J Y,Shin S G,Kim S C,Heo D S,Kim N K,Bang Y J.Clin Cancer Re,2004,10(1):3708~3716
28 Hamaguchi T,Kato K,Yasui H,Morizane C,Ikeda M,Ueno H,Muro K,Yamada Y,Okusaka T,Shirao K,Shimada Y,Nakahama H,Matsumura Y.Bri J Cancer,2007,97(2):170~176
29 Hamaguchi T,Matsumura Y,Suzuki M,Shimizu K,Goda R,Nakamura I,Nakatomi I,Yokoyama M,Kataoka K,Kakizoe T.Bri J Cancer,2005,92(7):1240~1246
30 Negishi T,Koizumi F,Uchino H,Kuroda J,Kawaguchi T,Naito S,Matsumura Y.Bri J Cancer,2006,95(5):601~606
31 Zhang X F,Li Y X,Chen X S,Wang X H,Xu X Y,Liang Q Z,Hu J,Jing X.Biomaterials,2005,26(14):2121~2128
32 Xie Z,Guan H,Chen X,Lu C,Chen L,Hu X,Shi Q,Jing X.J Control Release,2007,117(2):210~216
33 Shahin M,Lavasanifar A.Int J Pharmaceut,2010,389(1-2):213~222
34 Gong J,Chen M,Zheng Y,Wang S,Wang Y.J Control Release,2012,159(3):312~323
35 Matsumura Y,Hamaguchi T,Ura T,Muro K,Yamada Y,Shimada Y,Shirao K,Okusak T,Ueno H,Ikeda M,Watanabe N.Bri J Cancer,2004,91(10):1775~1781
36 Yang J,Liu W,Sui M,Tang J,Shen Y.Biomaterials,2011,32(34):9136~9143
37 Wang J,Liu W,Tu Q,Wang J,Song N,Zhang Y,Nie N,Wang J.Biomacromolecules,2011,12(1):228~234
38 Clementi C,Miller K,Mero A,Mol Pharmaceut,2011,8(4):1063~1072
39 Miller K,Eldar-Boock A,Polyak D,Segal E,Benayoun L,Shaked Y,Satchi-Fainaro R.Mol Pharmaceut,2011,8(4):1052~1062
40 Etrych T,Sirova M,Starovoytova L,Rihova B,Ulbrich K.Mol Pharmaceut,2010,7(4):1015~1026
41 Chen W,Shi Y,Feng H,Du M,Zhang J Z,Hu J,Yang D.J Phys Chem B,2012,116(30):9231~9237
42 Grundker C,Volker P,Griesinger F,Ramaswamy A,Nagy A,Schally A V,Emons G.Am J Obstet Gynecol,2002,187(3):528~537
43 Koppan M,Nagy A,Schally A V,Plonowski A,Halmos G,Arencibia J M,Groot K.Prostate,1999,38(2):151~158
44 Nagy A,Schally A V,Armatis P,Szepeshazi K,Halmos G,Kovacs M,Zarandi M,Groot K,Miyazaki M,Jungwirth A,Horvath J.PNAS,1996,93(14):7269~7273
45 Tong R,Cheng J.J Am Chem Soc,2009,131(13):4744~4754
46 Etrych T,Chytil P,Jelinkova M,Rihova B,Ulbrich K.Macromol Biosci,2002,2(1):43~52
47 Hruby M,Konak C,Ulbrich K.J Control Release,2005,103(1):137~148
48 Nakanishi T,Fukushima S,Okamoto K,Suzuki M,Matsumura Y,Yokoyama M,Okano T,Sakurai Y,Kataoka K.J Control Release,2001,74(1-3):295~302
49 Mo G,Hu X,Liu S,Yue J,Wang R,Huang Y,Jing X.Eur J Pharm Sci,2012,46(5):329~335
50 Hu X,Liu S,Huang Y,Chen X,Jing X.Biomacromolecules,2010,11(8):2094~2102
51 Hu X,Wang R,Yue J,Liu S,Xie Z,Jing X.J Mater Chem,2012,22:13303~13310
52 Zhan F,Chen W,Wang Z,Lu W,Cheng R,Deng C,Meng F,Liu H,Zhong Z.Biomacromolecules,2011,12:3612~3620
53 Zhou L,Cheng R,Tao H,Ma S,Guo W,Meng F,Liu H,Liu Z,Zhong Z.Biomacromolecules,2011,12:1460~1467
54 MacKay J A,Chen M,McDaniel J R,Liu W,Simnick A J,Chilkoti A.Nat Mater,2009,8(12):993~999
55 Lee C C,Gillies E R,Fox ME,Guillaudeu S J,Frechet J M J,Dy E E,Szoka F C,PNAS,2006,103(45):16649~16654
56 Cleare M J,Hydes P C,Malerbi B W,Watkins D M.Biochimie,1978,60(9):835~850
57 Reithofer M R,Valiahdi S M,Jakupec M A,Arion V B,Egger A,Galanski M,Keppler B K.J Med Chem,2007,50(26):6692~6699
58 Kolishetti N,Dhar S,Valencia P M,Lin L Q,Karnik R,Lippard S J,Langer R,Farokhzad,O C.PNAS,2010,107(42):17939~17944
59 Xiao H,Qi R,Liu S,Hu X,Duan T,Zheng Y,Huang Y,Jing X.Biomaterials,2011,32(30):7732~7739
60 Dhar S,Daniel W L,Giljohann D A,Mirkin C A,Lippard S J.J Am Chem Soc,2010;132(48):17335
61 Farrer N J,Woods J A,Munk V P,Mackay F S,Sadler P J.Chem Res Toxicol,2010,23(2):413~421
62 Bednarski P J,Mackay F S,Sadler P J.Anti-Cancer Agent Me,2007,7(1):75~93
63 Kasparkova J,Mackay F S,Brabec V,Sadler P J.J Biol Inorg Chem,2003,8(7):741~745
64 Wheate N J,Collins J G.Curr Med Chem,2005,5(3):267~279
65 Wheate N J,Collins J G.Coordin Chem Rev,2003,241(1-2):133~145
66 Nishiyama N,Yokoyama M,Aoyagi T,Okano T,Sakurai Y,Kataoka K.Langmuir,1999,15(2):377~383
67 Nishiyama N,Kato Y,Sugiyama Y,Kataoka K.Pharmaceut Res,2001,18(7):1035~1041
68 Cabral H,Nishlyama N,Kataoka K.J Control Release,2007,121(3):146~155
69 Osada K,Christie R J,Kataoka K.J Roy Soc,2009,6:S325~S39
70 Uchino H,Matsumura Y,Negishi T,Koizumi F,Hayashi T,Honda T,Nishiyama N,Kataoka K,Naito S,Kakizoe T.Bri J Cancer,2005,93(6):678~687
71 Sood P,Thurmond K B,II,Jacob J E,Waller L K,Silva G O,Stewart D R.Bioconjugate Chem,2006,17(5):1270~1279
72 Nowotnik D P,Cvitkovic E.Adv Drug Del Rev,2009,61(13):1214~1219
73 Rademaker-Lakhai J M,Terret C,Howell S B,Baud C M,de Boer R F,Pluim D,Beijnen J H,Schellens J H M,Droz J P.Clin Cancer Res,2004,10(10):3386~3395
74 Lin X,Zhang Q,Rice J R,Stewart D R,Nowotnik D P,Howell S B.Eur J Cancer,2004,40(2):291~297
75 Gianasi E,Buckley R G,Latigo J,Wasil M,Duncan R.J Drug Target,2002,10(7):549~556
76 Xiao H,Zhou D,Liu S,Qi R,Zheng Y,Huang Y,Jing X.Macromol Biosci,2012,12(3):367~373
77 Xiao H,Zhou D,Liu S,Zheng Y,Huang Y,Jing X.Acta Biomater,2012,8(5):1859~1868
78 Rieter W J,Pott K M,Taylor KML,Lin W.J Am Chem Soc,2008,130(35):11584
79 Feazell R P,Nakayama-Ratchford N,Dai H,Lippard S J.J Am Chem Soc,2007,129(27):8438
80 Dhar S,Daniel W L,Giljohann D A,Mirkin C A,Lippard S J.J Am Chem Soc,2009,131(41):14652
81 Dhar S,Kolishetti N,Lippard S J,Farokhzad O C.PNAS,2011,108(5):1850~1855
82 Xiao H,Song H,Yang Q,Cai H,Qi R,Yan L,Liu S,Zheng Y,Huang Y,Liu T,Jing X.Biomaterials,2012,33(27):6507~6519
83 Song H,Wang R,Xiao H,Cai H,Zhang W,Xie Z,Huang Y,Jing X,Liu T.Euro J Pharm Biopharm,2013,83:63~75
84 Brabec V,Kasparkova J,Vrana O,Novakova O,Cox J W,Qu Y,Farrell N.Biochemistry,1999,38(21):6781~6790
85 Kasparkova J,Zehnulova J,Farrell N,Brabec V.J Biol Chem,2002,277(50):48076~48086
86 Wheate N J,Buck D P,Day A I,Collins J G.Dalton T,2006,(3):451~458
87 Xiao H,Song H,Zhang Y,Qi R,Wang R,Xie Z,Huang Y,Li Y,Wu Y,Jing X.Biomaterials,2012,33(33):8657~8669
88 Wang R,Hu X,Xiao H,Xie Z,Huang Y,Jing X.J Mater Chem B,2013,1:744~748
89 Chen F,Dong D,Fu Y,Zheng Y,Liu S,Chang M,Jing X.Chem Res Chinese Universities,2012,28(4):656~661
90 Yoo H S,Park T G.J Control Release,2004,100(2):247~256
91 Bae Y,Jang WD,Nishiyama N,Fukushima S,Kataoka K.Mol Biosyst,2005,1(3):242~250
92 Julyan P J,Seymour L W,Ferry D R,Daryani S,Boivin C M,Doran J,David M,Anderson D,Christodoulou C,Young A M,Hesslewood S,Kerr D J.J Control Release,1999,57(3):281~290
93 Ferry D R,Seymour L W,Anderson D,Hesselwood S,Julyan P,Boivin C,Poyner R,Guest P,Doran J,Kerr D J.Cancer,1999,80:21
94 Hu Z,Luo F,Pan Y,Hou C,Ren L,Chen J,Wang J,Zhang Y.J Biomed Mater Res A,2008,85A(3):797~807
95 Xiao H,Li W,Qi R,Yan L,Wang R,Liu S,Zheng Y,Xie Z,Huang Y,Jing X.J Control Release,2012,163:304~314
96 Song H,Xiao H,Zhang Y,Cai H,Wang R,Zheng Y,Huang Y,Li Y,Xie Z,Liu T,Jing X.J Mater Chem B,2013,1:762~772
97 Xiao H,Yan L,Zhang Y,Qi R,Li W,Wang R,Liu S,Huang Y,Li Y,Jing X.Chem Commun,2012,48:10730~10732
98 Wang R,Xiao H,Song H,Zhang Y,Hu X,Xie Z,Huang Y,Jing X,Li Y.J Mater Chem,2012,22:25453~25462

[1] 周念恩;陈衢生;卓仁禧. 高分子药物研究——ⅩⅦ. 二羟烷基嘧啶与N,N’-双(2-氯乙基) 二氯磷酰胺缩聚物的合成及其抗肿瘤活性研究[J]. Acta Polymerica Sinica, 1987, 1(6): 417-422.

[2] 陈衢生;卓仁禧;周念恩. 高分子药物研究——ⅪⅤ.含核酸碱基和氮芥的聚磷酸酯的合成及其抗肿瘤活性初步研究[J]. Acta Polymerica Sinica, 1987, 1(3): 216-221.

  本文关键词：高分子药物学的研究进展与期盼，由笔耕文化传播整理发布。