军队老年人轻度认知损害向Alzheimer病转化的5年随访研究

发布时间：2018-06-12 02:46

本文选题：轻度认知损害 + 阿尔茨海默病　；参考：《首都医科大学学报》2008年03期

【摘要】：目的研究军队老年人轻度认知损害(MCI)向Alzheimer病(AD)的转化率,为进一步研究AD提供依据。方法以2001年石家庄市26个部队干休所进行MCI患病率调查的2674名60岁及以上的离退休干部为研究对象,对调查时诊断为MCI的216例患者(平均年龄74.2岁)和2302名认知正常的受试者(平均年龄73.9岁)进行为期5年的队列研究,探讨MCI患者向AD的转化率及MCI患者与认知正常的受试者相比较转化为AD的相对危险性(RR)和95%可信区间(95%CI)。结果随访5年后MCI患者的死亡率为7.9%,认知正常受试者为3.4%,差异有统计学意义(P=0.001);老年MCI患者在随访第3年时有16.8%进展为AD,第5年时则有33.7%进展为AD;MCI患者向AD的平均年转化率为6.7/百人年(95%CI=5.4～8.0),认知正常的老年人AD的平均年发病率为0.8/百人年(95%CI=0.6～1.0);男性和女性MCI患者AD的平均年发病率差异无统计学意义(P=0.62);随着文化程度的提高,MCI患者AD的平均年发病率有降低的趋势(P=0.03);MCI患者转化为AD的相对危险性为认知正常者的8.1倍(95%CI=6.1～10.6,P0.0001)。结论军队老年MCI患者转化为AD的危险性远大于认知正常的老年人,应加强对老年MCI患者这一AD高危人群的监测。
[Abstract]:Objective to study the conversion rate of mild cognitive impairment (MCI) to Alzheimer disease (AD) in the army, and to provide the basis for further study of AD. Methods 2674 retired cadres who were 60 years old and above were investigated with the prevalence of MCI in 26 troops in Shijiazhuang in 2001. The average age of 216 patients diagnosed as MCI (average age 74) was 74. .2 years old and 2302 normal subjects (average age 73.9 years) conducted a 5 year cohort study to explore the conversion rate of MCI patients to AD and the relative risk (RR) and 95% confidence interval (95%CI) of MCI patients and cognitive subjects. The mortality of MCI patients was 7.9% after 5 years of follow-up, and the cognitive normal subjects were tested. The difference was 3.4%, the difference was statistically significant (P=0.001); in the elderly MCI patients, 16.8% were AD and 33.7% were AD at fifth years; the average annual conversion rate of MCI patients to AD was 6.7/ hundred years (95%CI=5.4 to 8), and the average annual incidence of AD in normal cognitive elderly was 0.8/ hundred years (95%CI=0.6 to 1); male and female MC. There was no significant difference in the average annual incidence of AD in I patients (P=0.62). With the improvement of cultural level, the average annual incidence of AD in MCI patients had a decreasing trend (P=0.03); the relative risk of MCI patients converted to AD was 8.1 times as much as those in the normal cognition (95%CI=6.1 to 10.6, P0.0001). In the elderly with normal cognition, we should strengthen the monitoring of the high-risk population of MCI in elderly patients with AD.
【作者单位】：
【基金】：全军“十五”医药重点课题(01Z2037)资助项目~~
【分类号】：R82

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