模拟常压失事潜艇环境人血细胞表面CD55、CD59分布的变化

发布时间：2018-06-14 08:14

本文选题：失事潜艇 + 淋巴细胞　；参考：《中国应用生理学杂志》2007年02期

【摘要】：目的探讨模拟固壳未破损失事潜艇环境条件暴露对人体血液免疫功能的影响及其变化的规律。方法使用500m饱和潜水居住舱系统模拟失事潜艇固壳未破损舱室环境条件,控制舱内温度、PCO2、PO2,于进舱前、暴露第2、4、8d采晨空腹血,用流式细胞分析术测定红细胞、淋巴细胞、中性粒细胞表面CD55和CD59的分布变化。结果红细胞膜表面CD55的分布在8d有显著升高(P0.01);淋巴细胞膜表面CD55的分布在暴露的初、中期显著下降(P0.01),后期明显恢复,与温度、PO2呈正相关(P0.01),与PCO2呈负相关(P0.01),CD59分布的变化与CD55变化类似。结论氧分压和环境温度过低、二氧化碳分压过
[Abstract]:Objective to investigate the effect of environmental exposure on human blood immune function and its changes in simulated undamaged shipwrecked submarine. Methods the 500m saturated submersible cabin system was used to simulate the environmental conditions of the intact cabin of the shipwrecked submarine. The temperature of the cabin was controlled by PCO2PO2. The fasting blood was collected at the 4th day of exposure for 8 days, and the red blood cells and lymphocytes were measured by flow cytometry. Distribution of CD55 and CD59 on neutrophil surface. Results the distribution of CD55 on erythrocyte membrane was significantly increased at 8 days, and the distribution of CD55 on lymphocyte membrane was significantly decreased at the beginning of exposure, decreased significantly in the middle stage, and recovered significantly at the later stage. There was a positive correlation with the temperature of PO2 and a negative correlation with PCO2. The distribution of CD59 was similar to that of CD55. Conclusion the partial pressure of oxygen and ambient temperature is too low, and the partial pressure of carbon dioxide is too low.
【作者单位】：海军医学研究所海军医学研究所第二军医大学长海医院海军医学研究所海军医学研究所海军医学研究所海军医学研究所海军医学研究所海军医学研究所
【基金】：海军后勤部卫生部科研基金课题(03-3303)
【分类号】：R84

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