脉冲与脉冲稳态复合型强噪声对豚鼠听觉器官的影响

发布时间：2018-06-28 10:33

本文选题：脉冲噪声 + 稳态噪声　；参考：《航天医学与医学工程》2004年06期

【摘要】：目的研究不同强度脉冲噪声与脉冲稳态复合型高强噪声对豚鼠听觉器官的影响。方法 48只豚鼠随机分为对照组 (C)、5次 1 5 1dB (Ps,TB=2 0ms)脉冲组 (P1 )、9次 1 5 1dB脉冲组 (P2 )、9次 1 5 5dB脉冲组 (P3)、9次 1 5 5dB脉冲加 1 1 0dB稳态噪声复合组 (Com1 )、5次 1 5 5dB脉冲加 1 1 8dB稳态噪声复合组 (Com2 ) ,每组 8只。检测噪声暴露前后中耳损伤、ABR听阈及 1周后的毛细胞变化。结果中耳无明显损伤 ;暴露后即刻、2 4h各暴露组均有明显的暂时性听力损失 (P 0 .0 1 ) ,1周后 ,复合噪声组听力仍未完全恢复 (P 0 .0 5 ) ;各暴露组的毛细胞均有不同程度缺损 ,并伴有基底膜变薄内陷。结论脉冲噪声可引起豚鼠暂时性听力损失 ,并造成毛细胞部分缺损 ,复合高强度的稳态噪声时 ,可造成豚鼠永久性听力损失。
[Abstract]:Objective to study the effect of pulse noise of different intensity and high intensity noise of pulse steady state on hearing organ of guinea pig. Methods Forty-eight guinea pigs were randomly divided into control group (C) 5 times 151dB (PsTBN 2 0ms) pulse group (P1) 9 times 151dB pulse group (P2) 9 times 155dB pulse group (P3) 9 times 155dB pulse plus 10 dB steady-state noise compound group. (Com1) 5 times 155dB pulse plus 118dB steady-state noise complex (Com2), There were 8 rats in each group. The ABR hearing threshold of middle ear injury before and after noise exposure and the changes of hair cells 1 week later were detected. Results there was no obvious damage to the middle ear, and there was significant temporary hearing loss at 24 h after exposure (P0. 01). After 1 week, the hearing of the compound noise group was not completely recovered (P0. 05). The hair cells of each exposure group had varying degrees of defect, accompanied by thinning and invagination of the basement membrane. Conclusion Pulsed noise can cause temporary hearing loss and some hair cell defects in guinea pigs, and can cause permanent hearing loss in guinea pigs when combined with high intensity steady-state noise.
【作者单位】：航天医学工程研究所航天医学工程研究所航天医学工程研究所航天医学工程研究所航天医学工程研究所航天医学工程研究所
【基金】：中国载人航天工程基金资助
【分类号】：R852.83

【共引文献】