服用莫达非尼对48h睡眠剥夺条件下模拟飞行操作能力的影响

发布时间：2018-07-02 19:29

本文选题：睡眠剥夺 + 中枢神经系统药物　；参考：《航天医学与医学工程》2006年02期

【摘要】：目的观察48 h睡眠剥夺(sleep deprivation,SD)条件下正常人服用莫达非尼改善模拟器飞行操作能力的效果。方法以6名健康男性青年志愿者为对象,在间隔2周的两次48 h SD(从第1天8:00至第3天8:00)实验中交叉服用莫达非尼和安慰剂(于实验第2天0:00、16:00和第3天0:00服用,每次200 mg),于第1天21:00及每次服药后1 h3、h、5 h、7 h进行J7-E模拟器飞行操作测试。结果安慰剂组的模拟器飞行成绩随SD时间延长逐渐下降,在第3天1:00~7:00的飞行成绩明显降低;操作错误随着SD延长而增加,在第3天1:00~7:00的出错次数增多,并且左上转弯和着陆阶段的操纵错误较多。与安慰剂组相比,莫达非尼组的飞行成绩在第3次服药后明显提高。莫达非尼组48 h SD总的操作错误数较安慰剂组降低了19%,第3天1:00~7:00的错误数较安慰剂组降低了40%。结论服用莫达非尼明显改善48 h SD条件下的模拟飞行操作能力,在SD复合生物节律的影响时药效更明显。
[Abstract]:Objective to observe the effect of modafenib on the flight performance of the simulator in normal subjects under 48 h sleep deprivation (sleep de privation SD). Methods six healthy young male volunteers were cross-administered with Modafenib and placebo (0: 00: 16: 00 on the second day and 0:00 on the third day) in two 48 h SD trials at intervals of 2 weeks (from 8:00 on the first day to 8:00 on the third day). The flight operation of J7-E simulator was tested at 21:00 on day 1 and 5 hours after administration of 200 mg),. Results the flight performance of the simulator in the placebo group decreased gradually with the prolongation of SD time, and decreased significantly at 1: 00 to 7: 00 on the 3rd day, the error of operation increased with the prolongation of SD, and the number of errors at 1: 00: 700 increased on the third day. And the left-up turn and landing phase of the control error is more. Compared with the placebo group, the flight performance of the modafinil group was significantly improved after the third dose. The total number of SD operating errors in the modafenil group at 48 h was 19 lower than that in the placebo group, and the number of errors at 1: 00 to 7: 00 on the third day was 40% lower than that in the placebo group. Conclusion Modafenib can obviously improve the simulated flight operation ability under 48 h SD, and the effect is more obvious when the compound biological rhythm of SD is affected.
【作者单位】：空军航空医学研究所空军航空医学研究所空军航空医学研究所空军航空医学研究所空军航空医学研究所空军航空医学研究所空军航空医学研究所
【基金】：空军后勤科研计划项目(KH0108011)
【分类号】：R85

【相似文献】