45Hz全身振动预防尾吊模型大鼠骨质丢失的研究

发布时间：2018-07-07 22:23

本文选题：低频全身振动 + 骨质丢失　；参考：《中国康复医学杂志》2009年03期

【摘要】：目的:探讨低频全身振动对尾吊大鼠骨质丢失的预防效果。方法:28只雄性成年大鼠,随机分为4组:尾部悬吊组(SUS),尾部悬吊+地面刺激组(S+G,地面刺激:15min/d,5d/周),尾部悬吊+振动刺激组(S+V,振动刺激:45Hz,0.2—0.5g,15min/d,5d/周)及对照组(CON)。8周后,对各组股骨骨密度(BMD),血清中钙(Ca),磷(P),碱性磷酸酶(ALP)含量及胫骨的三点弯曲实验进行了观察。结果:经过8周的悬吊,S+V组股骨头(主要为松质骨)骨密度明显高于SUS和S+G组,但仍低于CON组(P0.05)。而股骨中段(主要为皮质骨)骨密度在各组之间没有明显差别(P0.05)。三点弯曲结果显示S+V组胫骨最大载荷和刚度系数与S+G组和SUS组之间没有显著差异(P0.05)。血清中Ca,P,ALP含量在各组之间差异没有显著性意义。结论:45Hz低频全身振动能在一定程度上延缓尾吊大鼠的后肢骨质丢失现象,提示其具备了成为长期失重飞行防护措施的可能。
[Abstract]:Objective: to investigate the prevention effect of low-frequency whole-body vibration on bone loss in tail-suspended rats. Methods Twenty eight adult male rats were randomly divided into four groups: tail suspension group (SUS), tail suspension ground stimulation group (S G), tail suspension vibration group (S V) and control group (Con). Bone mineral density (BMD), serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP) and tibia were measured. Results: the bone mineral density (BMD) of femoral head (mainly cancellous bone) in SV group was significantly higher than that in SUS and S G groups, but still lower than that in Con group (P0.05). The bone mineral density of the middle femur (mainly cortical bone) had no significant difference among the groups (P0.05). The results of three-point bending showed that there was no significant difference in tibial maximum load and stiffness coefficient between SV group and S G group and SUS group (P0.05). There was no significant difference in ALP content among the groups. Conclusion low frequency whole body vibration of 15 Hz can delay the bone loss of hind limb of tail suspension rats to some extent, which suggests that it is possible to become a long-term flight protection for weightlessness.
【作者单位】：北京理工大学机械与车辆工程学院生物力学实验室;中国航天员科研训练中心重力生理实验室;香港理工大学健康技术与信息系;
【基金】：载人航天基础研究课题(SJ200605) 香港理工大学基础研究基金(1-BB81)
【分类号】：R85

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