生物陶瓷药物载体应用于海水浸泡爆炸伤的实验研究

发布时间：2018-07-14 08:04

【摘要】：目的　观察生物陶瓷药物载体应用于海水浸泡爆炸伤伤口的效果 ,探讨推迟初期外科处理时间的措施。　方法　健康大白兔 16只 ,造成后肢软组织爆炸伤合并海水浸泡 1h ,然后随机分为药物组 (兔数 =8)和对照组 (兔数 =8)。在药物组伤口内放置盛装环丙沙星与吲哚美辛的生物陶瓷载体 ,对照组伤口放置无药物的陶瓷载体 ,测定伤后 6～ 3 6h内浸泡的爆炸伤组织的细菌数、三磷酸腺苷 (ATP)含量、组织压力的改变 ,观察组织病理形态学变化。　结果　伤后 6～ 3 6h内药物组爆炸伤组织细菌数为每克组织 1× 10 4 左右 ,对照组细菌数高达每克组织 1× 10 6 ～ 1× 10 7,药物组爆炸伤组织ATP为对照组的 1.4 1～ 2 .5 3倍 ,组织压力明显低于对照组 ,继发损伤程度以及炎症反应减轻。　结论　生物陶瓷药物载体在海水浸泡爆炸伤伤口中的应用 ,有助于防止感染的发生 ,减轻炎症反应 ,推迟初期外科处理的时间
[Abstract]:Objective to observe the effect of bioceramic drug carrier in seawater immersion and explosive wound and to explore the measures to delay the initial surgical treatment. Methods 16 healthy rabbits were used. The rats were divided into two groups randomly: drug group (rabbit number 8) and control group (rabbit number 8). The bioceramic carriers containing ciprofloxacin and indomethacin were placed in the wounds of the drug group and those in the control group were placed without drugs. The number of bacteria in explosive wound tissues soaked within 6 ~ 36 hours after injury was determined. The changes of ATP content, tissue pressure and histopathology were observed. Results the number of bacteria in explosive tissue of drug group was about 1 脳 10 4 per gram of tissue within 6 ~ 36 hours after injury. The number of bacteria in the control group was 1 脳 10 6 ~ 1 脳 10 7 per gram, and ATP in explosive injury tissue in the drug group was 1.41 ~ 25.53 times of that in the control group, and the tissue pressure was significantly lower than that in the control group. Conclusion the application of bioceramic drug carrier in the mouth of seawater immersion explosive wound is helpful to prevent infection, alleviate inflammatory reaction and delay the time of initial surgical treatment
【作者单位】：第三军医大学附属大坪医院野战外科研究所第六研究室第三军医大学附属大坪医院野战外科研究所第四研究室第三军医大学附属大坪医院野战外科研究所第六研究室第三军医大学附属大坪医院野战外科研究所第六研究室
【基金】：全军“十五”医药卫生指令性课题资助项目 ( 0 1L0 11)
【分类号】：R826.5

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