内蒙高原实验性爆炸伤某些病理生化改变与防护效果观察

发布时间：2018-08-07 11:35

【摘要】：目的 :观察内蒙高原条件下实验性声波冲击波伤复合火药中毒对动物组织形态学及某些生化指标的影响 ,为临床防护提供依据。方法 :用爆竹爆炸致伤 30只兔 ,用手榴弹炸伤鱼2 3尾 ,伤后作病理学检查 ,测定凝血酶元时间以及SOD、MDA。另 10只兔在采用自制防护装具和口服战伤 1号条件下进行陆地爆炸时防护效果观察。结果 :陆地和水下爆炸实验动物死亡率分别为 4 3%和 6 5 %。解剖发现动物脑、脊髓呈血瘀症改变以及胃出血 ,胸腔积血 ,肺破裂出血 ,胆囊、脾破裂出血。光学显微镜检查脑、脊髓细胞肿胀 ,血管内壁细胞肿胀 ,血流阻塞 ;凝血酶元时间延长 ;SOD降低 ,MDA升高。采用防护措施后 ,10只兔死亡 1只 ,解剖 3只发现脑轻度肿胀充血 ,肺挫伤 ,胆囊、胃、脾肿胀充血无破裂 ,其余 6只兔经急救处理后成活。结论 :实验性声波冲击波伤复合火药中毒可致组织形态严重损伤和某些生化改变 ,采用防护措施可预防爆炸时组织损伤 ,减少死亡率。
[Abstract]:Objective: to observe the effects of experimental sonic shock wave injury combined with gunpowder poisoning on histomorphology and some biochemical indexes of animals under the condition of Inner Mongolia plateau, and to provide evidence for clinical protection. Methods: 30 rabbits were injured by explosion of firecrackers and 23 fish were injured by hand grenade. Pathological examination was made after injury, and thrombin time and SOD MDAs were measured. The protective effects of 10 rabbits on land explosion were observed under the condition of self-made protective gear and oral injury 1. Results: the mortality rates of terrestrial and underwater explosive animals were 43% and 65%, respectively. The animal brain and spinal cord showed blood stasis, gastric hemorrhage, pleural hemorrhage, pulmonary rupture, gallbladder and spleen hemorrhage. The brain and spinal cord cells were swollen, the blood flow was blocked and the thrombin time was prolonged. After protective measures, 10 rabbits died, and 3 rabbits were found to have mild brain swelling and congestion, lung contusion, gallbladder, stomach and spleen swelling without rupture. The other 6 rabbits survived after first aid treatment. Conclusion: experimental sonic shock wave injury combined with gunpowder poisoning can cause serious damage of tissue morphology and some biochemical changes. Protective measures can prevent tissue damage and reduce mortality.
【作者单位】：解放军第二五三医院内蒙陆军预备役部队第三军医大学野战外科研究所第三军医大学野战外科研究所解放军第二五三医院解放军第二五三医院解放军第二五三医院
【分类号】：R82

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