解除模拟失重后清醒大鼠血压信号的谱分析

发布时间：2018-08-24 14:10

【摘要】：本文旨在观察模拟失重28d大鼠解除尾部悬吊前、后(2h内),清醒自由活动状态下动脉收缩压(systolic bloodpressure, SBP)、舒张压(diastolic blood pessure, DBP)和心率(heart rate,HR)的变化。采用自回归模型法对不同时间点的收缩压变异性(SBP variability, SBPV)和心率变异性(HR variability, HRV)进行自谱与互谱分析,并比较自回归法与周期图法的自谱分析结果;由传递函数分析得到反映压力感受器-心率反射敏感性(baroreceptor-heart rate reflex sensitivity, BRS)变化的有关数据。结果显示,用自回归模型法对清醒大鼠血压信号进行短时程谱分析可得到较为平滑、谱峰清楚的谱估计曲线。28d模拟失重大鼠解除尾部悬吊前、后,SBP、DBP和HR及其主要谱指标,以及高、低频段传递函数的平均增益均无显著性变化,不同时间点的谱指标也无显著差别;但模拟失重组的SBP、DBP和HR却显著高于对照组。上述结果提示,中期模拟失重大鼠恢复正常体位后,其清醒状态的BPV与HR均处于升高状态,但其短时程BPV与HRV谱及BRS均无显著变化,与最近报道的航天员HRV与BRS无显著改变一致。
[Abstract]:The purpose of this study was to observe the changes of arterial systolic blood pressure (systolic bloodpressure, SBP),) diastolic pressure (diastolic blood pessure, DBP) and heart rate (heart rate,HR) in rats with simulated weightlessness for 28 days before and after release of tail suspension (within 2 hours). Autoregressive model was used to analyze systolic pressure variability (SBP variability, SBPV) and heart rate variability (HR variability, HRV) at different time points. The autospectral analysis results of autoregressive method and period chart method were compared. The data of heart rate reflex sensitivity (baroreceptor-heart rate reflex sensitivity, BRS) was obtained by transfer function analysis. The results showed that using autoregressive model to analyze the blood pressure signals of awake rats in a short time course, the spectral estimation curve with clear spectral peak. 28d simulated weightlessness rats before lifting tail suspension, then SBP DBP and HR and their main spectral indexes. There was no significant change in the average gain of the transfer function in the high and low frequency bands, and no significant difference in spectral indices at different time points, but the SBP,DBP and HR in simulated lost recombination were significantly higher than those in the control group. The above results suggest that the BPV and HR of the rats in the waking state are elevated after returning to normal posture, but the short-term BPV and HRV spectra and BRS have no significant changes in the short term simulated weightlessness rats. There was no significant change in HRV and BRS with recent reports.
【作者单位】：第四军医大学航空航天生理学教研室南安普敦大学声学与振动研究所第四军医大学航空航天生理学教研室第四军医大学计算机应用教研室第四军医大学计算机应用教研室第四军医大学航空航天生理学教研室
【基金】：supported by the National Natural Science Foundation of China (No. 30570677)
【分类号】：R852

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