不同角度倾斜对人体心血管系统影响的仿真研究

发布时间：2018-08-26 12:15

【摘要】：目的仿真研究不同角度倾斜对人体心血管系统血液动力学的影响,并与已发表实验数据比较,以校验所用分布式心血管系统数学模型是否可用于失重对心血管影响的仿真研究,提出存在问题及改进方向。方法利用该模型沿血管方向调整重力分量模拟人体倾斜角度的变化,计算变化过程中人体的心血管响应。结果随倾斜角度绝对值的增加,所有血管的平均血压都近似呈不同方向的指数变化。人体由直立体位转至水平体位,中心静脉压呈指数增加;心率虽呈指数降低,但变化幅度很小;每搏量呈线性增加。静脉系统的流体静压参考点位于右心房和下腔静脉之间。仿真结果与报道的人体倾斜或卧床实验数据相近。结论该模型可以有效地模拟人体倾斜角度变化时心血管系统的急性响应;但为了仿真长期航天失重环境下心血管系统的适应性变化,还需将血量调节,心脏与血管功能和结构的慢性适应变化,以及神经-体液调节等机制耦合进来。
[Abstract]:Objective to study the effects of different angle tilt on the hemodynamics of human cardiovascular system, and compare with the published experimental data to verify whether the distributed cardiovascular system mathematical model can be used to simulate the cardiovascular effects of weightlessness. The existing problems and the direction of improvement are put forward. Methods the model was used to adjust the gravity component along the direction of the blood vessel to simulate the change of the tilt angle of human body and to calculate the cardiovascular response in the course of the change. Results with the increase of the absolute value of tilt angle, the mean blood pressure of all blood vessels changed exponentially in different directions. The central venous pressure increased exponentially, the heart rate decreased exponentially, but the range of change was small, and the volume of stroke increased linearly. The hydrostatic pressure reference point of the venous system lies between the right atrium and the inferior vena cava. The simulation results are close to the reported experimental data of human body tilt or bed rest. Conclusion the model can effectively simulate the acute response of cardiovascular system when the human body tilt angle changes, but in order to simulate the adaptive changes of cardiovascular system in long-term space weightlessness environment, it is necessary to regulate the blood volume. Chronic adaptation of heart and vascular function and structure, and neurohumoral regulation are coupled in.
【作者单位】：第四军医大学计算机应用教研室;第四军医大学航空航天生理教研室;
【基金】：国家自然科学基金(30470490) 军队医药卫生科研基金(06MA225)
【分类号】：R85

【共引文献】