经皮肌肉电刺激对尾部悬吊大鼠骨丢失防护的初步研究

发布时间：2018-10-09 09:55

【摘要】：目的进一步评估经皮肌肉电刺激(PMES)对尾部悬吊大鼠骨丢失的防护作用。方法17只雄性SD大鼠随机分为3组:自由对照组(Con)4只,尾吊组(TS)7只,尾吊且PMES组(TS+PMES)6只。用频率50Hz且幅度3mA的电流对右侧臀中肌进行刺激,1h/d,共26d。实验结束后测量所有大鼠股骨近端、中段和远端的骨密度(BMD)。结果对于右侧股骨近端BMD,3组之间均无显著性差别。对于右侧股骨中段BMD,Con组与其它组都存在显著性差别(P0.05),而其它2组无显著性差别。对于右侧股骨远端BMD,TS组与其它组都存在非常显著的差别(P0.01),而其它2组无显著性差别。结论尾部悬吊大鼠股骨骨丢失发生在中段和远端,PMES可以对抗股骨远端的骨质疏松,保持正常的BMD。
[Abstract]:Objective to evaluate the protective effect of percutaneous muscle electrical stimulation (PMES) on bone loss in tail suspension rats. Methods Seventeen male SD rats were randomly divided into three groups: (Con) (n = 4), (TS) (n = 7) and (TS PMES) (n = 6). The right gluteal middle muscle was stimulated with the current of frequency 50Hz and amplitude 3mA for 1 h / d for 26 days. Bone mineral density (BMD).) of proximal, middle and distal femur in all rats were measured after the experiment. Results there was no significant difference between the BMD,3 group and the right proximal femur group. There was significant difference between the right femur BMD,Con group and other groups (P0.05), but there was no significant difference between the other two groups. There was a significant difference between the right distal femur BMD,TS group and other groups (P0.01), but there was no significant difference between the other two groups. Conclusion the bone loss of femur in caudal suspension rats occurred in the middle and distal segments of femur, and PMES could resist osteoporosis of distal femur and maintain normal BMD..
【作者单位】：清华大学生物医学工程系清华大学生物医学工程系首都医科大学附属妇产医院清华大学生物医学工程系清华大学生物医学工程系清华大学生物医学工程系
【基金】：国家自然科学基金项目(60571013) 教育部博士点基金项目(20050003090)
【分类号】：R852.22

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