长链非编码RNA在肌肉分化发育及疾病中的研究进展
发布时间：2018-10-26 14:10
【摘要】：长链非编码RNA(long non-coding RNA,lncRNA)被证明在基因转录水平、转录后水平和表观遗传水平上发挥着重要的调控功能,进而影响疾病的发生,而肌肉的分化发育受到多种信号通路的调节。本文总结了长链非编码RNA的产生和作用方式,列出了调控肌肉分化发育的几种主要lncRNA,并讨论了肌肉疾病杜氏肌营养不良症(Duchenne muscular dystrophy,DMD)和面肩肱型肌营养不良症(facial muscular dystrophy,FSHD)中lncRNA的作用机制,为进一步探究lncRNA在肌肉分化发育疾病中的作用以及空间肌萎缩防护策略提供新的研究思路。
[Abstract]:Long chain noncoding RNA (long non-coding RNA,lncRNA) has been shown to play an important regulatory role in gene transcription, posttranscriptional and epigenetic levels, and thus affect the occurrence of disease. Muscle differentiation and development are regulated by multiple signaling pathways. In this paper, we summarized the production and action of long chain noncoding RNA, listed several main lncRNA, regulating muscle differentiation and development, and discussed muscle disease (Duchenne muscular dystrophy,DMD) and facial shoulder brachial dystrophy (facial muscular dystrophy,). The mechanism of lncRNA in FSHD provides a new way to study the role of lncRNA in muscle differentiation and development and the protective strategies of spatial muscle atrophy.
【作者单位】： 中国航天员科研训练中心航天医学基础与应用国家重点实验室;中国航天员科研训练中心人因工程重点实验室;
【基金】：国家自然科学基金(81501625,81401765) 人因工程重点实验室基金(SYFD140051801,SYFD150051802)
【分类号】：R85
，
本文编号：2295981
[Abstract]:Long chain noncoding RNA (long non-coding RNA,lncRNA) has been shown to play an important regulatory role in gene transcription, posttranscriptional and epigenetic levels, and thus affect the occurrence of disease. Muscle differentiation and development are regulated by multiple signaling pathways. In this paper, we summarized the production and action of long chain noncoding RNA, listed several main lncRNA, regulating muscle differentiation and development, and discussed muscle disease (Duchenne muscular dystrophy,DMD) and facial shoulder brachial dystrophy (facial muscular dystrophy,). The mechanism of lncRNA in FSHD provides a new way to study the role of lncRNA in muscle differentiation and development and the protective strategies of spatial muscle atrophy.
【作者单位】： 中国航天员科研训练中心航天医学基础与应用国家重点实验室;中国航天员科研训练中心人因工程重点实验室;
【基金】：国家自然科学基金(81501625,81401765) 人因工程重点实验室基金(SYFD140051801,SYFD150051802)
【分类号】：R85
，
本文编号：2295981
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