21d卧床期间血清碱性磷酸酶及电解质的变化
发布时间：2018-12-13 10:20
【摘要】：目的观察模拟失重对血清碱性磷酸酶 (ALP)及Ca2 +、Mg2 +、Cl- 、P3+代谢的影响。方法 6名健康男性志愿者 ,年龄 2 4 .8± 6.1岁 ,进行 2 1d头低位 ( - 6°)卧床试验。在卧床前第 3天 ,卧床第 3、1 0、2 1天及卧床后第 2天 (d + 2 )测定了被试者血清ALP及Ca2 +、Mg2 +、Cl- 、P3+含量的变化。血清Ca2 +测定用甲基麝香草酚蓝比色法 ,P3+测定用紫外分光光度法 ,Mg2 +和Cl- 测定用酶法 ,血清碱性磷酸酶测定用对 -硝基苯磷酸盐比色法。结果卧床期间 ,血清Ca2 +较卧床前显著增加 ,在卧床第 1 0天和 2 1天有统计学意义 (P 0 .0 1 ) ,卧床后第 2天仍显著高于卧床前 ;P3+在卧床第 2 1天和卧床前比较显著性降低 (P 0 .0 1) ;Mg2 +在卧床期间和卧床后均显著低于卧床前 (P 0 .0 5或P 0 .0 1 ) ;Cl- 在d2 1和d+ 2均较卧床前显著增加 (P 0 .0 1 )。血清碱性磷酸酶在卧床第 2 1天较卧床前显著增加 (P 0 .0 1 )。结论 2 1d头低位卧床过程中 ,血钙升高 ,血磷、镁降低 ,氯离子升高 ,血清ALP高于卧床前 ,可能反映机体处于代谢不平衡状态
[Abstract]:Objective to observe the effects of simulated weightlessness on serum alkaline phosphatase (ALP) and metabolism of Ca2, Mg2, Cl- and P3. Methods six healthy male volunteers, aged 24.8 卤6.1 years, underwent a 21 d headlow (- 6 掳) bed-rest test. The changes of serum ALP, Ca2, Mg2, Cl- and P3 in serum of the subjects were measured on the third day before bed rest, on the 3rd day after bed rest and on day 2 after bed rest. Serum Ca2 was determined by methyl thymol blue colorimetry, P3 by ultraviolet spectrophotometry, Mg2 and Cl- by enzymatic method, serum alkaline phosphatase by p-nitrophenyl phosphate colorimetry. Results during the period of bed rest, serum Ca2 level was significantly higher than that before bed rest (P < 0.01). There was a significant difference in serum Ca2 between 10 days and 21 days after bed rest (P < 0.01), and the second day after bed rest was still significantly higher than that before bed rest. P3 was significantly decreased on day 21 and before bed rest (P 0.01), and Mg2 was significantly lower during and after bed rest than that before bed rest (P 0.05 or P 0.01). Cl- on day 21 and d 2 were significantly higher than those before bed rest (P 0.01). Serum alkaline phosphatase was significantly increased on day 21 compared with that before bed rest (P 0.01). Conclusion during 21 d head-low bed rest, the serum calcium level increased, serum phosphorus and magnesium decreased, chloride ion increased, and serum ALP was higher than that before bed rest, which may indicate that the body is in an unbalanced state of metabolism.
【作者单位】： 第四军医大学航空航天生物动力学教研室 第四军医大学航空航天生物动力学教研室 空军临潼疗养院 空军临潼疗养院 第四军医大学航空航天生物动力学教研室 第四军医大学航空航天生物动力学教研室
【分类号】：R852.22
[Abstract]:Objective to observe the effects of simulated weightlessness on serum alkaline phosphatase (ALP) and metabolism of Ca2, Mg2, Cl- and P3. Methods six healthy male volunteers, aged 24.8 卤6.1 years, underwent a 21 d headlow (- 6 掳) bed-rest test. The changes of serum ALP, Ca2, Mg2, Cl- and P3 in serum of the subjects were measured on the third day before bed rest, on the 3rd day after bed rest and on day 2 after bed rest. Serum Ca2 was determined by methyl thymol blue colorimetry, P3 by ultraviolet spectrophotometry, Mg2 and Cl- by enzymatic method, serum alkaline phosphatase by p-nitrophenyl phosphate colorimetry. Results during the period of bed rest, serum Ca2 level was significantly higher than that before bed rest (P < 0.01). There was a significant difference in serum Ca2 between 10 days and 21 days after bed rest (P < 0.01), and the second day after bed rest was still significantly higher than that before bed rest. P3 was significantly decreased on day 21 and before bed rest (P 0.01), and Mg2 was significantly lower during and after bed rest than that before bed rest (P 0.05 or P 0.01). Cl- on day 21 and d 2 were significantly higher than those before bed rest (P 0.01). Serum alkaline phosphatase was significantly increased on day 21 compared with that before bed rest (P 0.01). Conclusion during 21 d head-low bed rest, the serum calcium level increased, serum phosphorus and magnesium decreased, chloride ion increased, and serum ALP was higher than that before bed rest, which may indicate that the body is in an unbalanced state of metabolism.
【作者单位】： 第四军医大学航空航天生物动力学教研室 第四军医大学航空航天生物动力学教研室 空军临潼疗养院 空军临潼疗养院 第四军医大学航空航天生物动力学教研室 第四军医大学航空航天生物动力学教研室
【分类号】：R852.22
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