南昌地区健康军人颈动脉内膜中膜厚度和粥样斑块形成的危险因素分析

发布时间：2019-01-05 13:22

【摘要】：目的了解南昌地区健康军人颈动脉平均内膜中膜厚度及粥样硬化斑块的形成情况并探讨健康军人动脉粥样硬化的危险因素。方法采用随机整群抽样的方法,选择南昌地区30岁以上健康军人,体格检查正常,收缩压140mmHg,舒张压90mmHg;入选后行颈动脉高频率B型超声检查,检查粥样硬化斑块的形成情况,测定颈动脉平均内膜中膜厚度。结果入选800人,颈动脉平均内膜中膜厚度随年龄明显增加(P0.01);随着年龄增加,性别对颈动脉平均内膜中膜厚度的影响存在差异,男性颈动脉平均内膜中膜厚度仅在40~49岁和50~59岁组明显高于女性(P值分别小于0.01和0.05)。224人检出颈动脉斑块,检出率为28.00%,随年龄明显增加(P0.01);随着年龄增加,性别对斑块发生率的影响也存在差异,男性斑块发生率仅在40~49岁组明显高于女性(P0.01)。年龄增加、男性和高低密度脂蛋白水平与颈动脉斑块和颈动脉平均内膜中膜厚度增厚均独立相关,而收缩压升高仅与颈动脉平均内膜中膜厚度增厚独立相关;40~49岁组男性低密度脂蛋白和收缩压水平均明显高于同龄女性(P0.01)。结论增龄、男性以及低密度脂蛋白水平虽然在正常范围内但是值偏高是颈动脉平均内膜中膜厚度增厚和动脉粥样硬化共同的独立危险因素,而收缩压在正常范围内值偏高仅是颈动脉平均内膜中膜厚度增厚的独立危险因素;男性和女性颈动脉颈动脉平均内膜中膜厚度和斑块形成随年龄增加的变化趋势存在明显差异,动脉粥样硬化的性别差异主要存在于40~49岁组。
[Abstract]:Objective to investigate the carotid mean intima-media thickness (IMT) and atherosclerotic plaque (Atheromatous plaque) in healthy soldiers in Nanchang area and to explore the risk factors of atherosclerosis. Methods A random cluster sampling method was used to select healthy soldiers over 30 years old in Nanchang area with normal physical examination, systolic blood pressure of 140 mm Hg and diastolic blood pressure of 90 mm Hg; The carotid artery high frequency B-mode ultrasound was used to examine the formation of atherosclerotic plaques and the mean intima media thickness of carotid artery was measured. Results the mean intima-media thickness of carotid artery increased significantly with age (P0.01). The effect of sex on the mean intima media thickness of carotid artery was different with age. The mean intima-media thickness of male carotid artery was significantly higher than that of female (P < 0.01 and P < 0.05) only in 40 ~ 49 years old group and 50 ~ 59 years old group (P < 0.05). The detection rate of carotid plaque in 224 cases was 28.00 and increased with age (P0.01). With the increase of age, the influence of gender on plaque incidence was also different. The incidence of plaque in male group was significantly higher than that in female group (P0.01). Age, male and high and low density lipoprotein levels were independently correlated with carotid plaque and carotid mean intima-media thickness, while systolic blood pressure was only correlated with carotid mean intima-media thickness. The low density lipoprotein (LDL) and systolic blood pressure (SBP) were significantly higher in males than in females of the same age (P0.01). Conclusion Age, men and low density lipoprotein (LDL) are independent risk factors for carotid intima-media thickening and atherosclerosis, although they are within normal range. The high systolic blood pressure in normal range was only an independent risk factor for carotid artery intima-media thickness. The mean intima media thickness and plaque formation of carotid artery in male and female were significantly different with age. The sex difference of atherosclerosis was mainly in 4049 years old group.
【作者单位】：中国人民解放军第94医院内一科南昌陆军学院中国人民解放军第94医院内一科中国人民解放军第94医院内一科中国人民解放军第94医院内一科中国人民解放军第94医院内一科中国人民解放军第94医院内一科
【分类号】：R82

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