推拉动作对脑组织一氧化氮、一氧化氮合酶及血浆内皮素的影响

发布时间：2019-02-15 12:37

【摘要】：为研究推拉动作对脑组织一氧化氮 (NO)、一氧化氮合酶 (NOS)及血浆内皮素 (ET)的影响 ,探讨推拉动作时在较低的G值即可发生加速度引起的意识丧失(G inducedlessofconsciousness,G LOC)的机制 ,给予大鼠高正加速度 (+Gz)及推拉动作暴露 ,并于暴露后30min、3h、1 2h、2 4h和 4 8h 5个时间点麻醉采血、取脑 ,测定脑组织NO、NOS及血浆中ET的含量。结果发现 ,+Gz和推拉动作组与正常组比较 ,脑组织中的NO、NOS及血浆中ET的含量在 30min、3h和 1 2h时增多 ,差异有显著性意义 (P 0 0 1 ) ,2 4h和 4 8h组间比较差异无显著性意义 (P 0 0 5 ) ;推拉动作组与 +Gz暴露组比较 ,30min、3h和 1 2h 3个时相点脑组织中的NO、NOS及血浆中ET的含量差异有显著性意义 (P 0 0 5 )。提示推拉动作暴露和单纯高 +Gz暴露可使大鼠脑组织NO与血浆ET的含量增多 ;且推拉动作暴露所致损伤程度更重
[Abstract]:To study the effect of push-pull action on nitric oxide (NO),) nitric oxide synthase (NOS) and plasma endothelin (ET) (ET) in brain tissue, and to explore the loss of consciousness induced by (G inducedlessofconsciousness, induced by acceleration at a lower G value in push-pull motion. The mechanism of G LOC) was given to rats with high positive acceleration (Gz) and push-pull action exposure. Blood samples were taken after 30 minutes of exposure at 12 h, 12 h, 24 h and 48 h after exposure, and brain NO, was measured at 5 time points (24 h and 48 h after exposure). The content of ET in NOS and plasma. The results showed that the contents of NO,NOS in brain tissue and ET in plasma in Gz and push-pull action group were significantly higher than those in normal group at 30 min and 12 h (P < 0.01). There was no significant difference between 24 h and 48 h groups (P 0.05). Compared with Gz exposure group, the contents of NO,NOS in brain tissue and ET in plasma were significantly different between push-pull action group and Gz exposure group at 30 min and 12 h (P < 0.05). The results suggest that the contents of NO and plasma ET in brain tissue can be increased by push-pull action exposure and high Gz exposure, and the degree of injury caused by push-pull action exposure is more serious.
【作者单位】：第四军医大学吉林军医学院第四军医大学吉林军医学院第四军医大学吉林军医学院第四军医大学吉林军医学院第四军医大学吉林军医学院第四军医大学吉林军医学院第四军医大学吉林军医学院第四军医大学吉林军医学院
【基金】：全军医学科研“十五”计划面上项目资助课题 (编号 0 1MA2 0 2 )
【分类号】：R85

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