呼吸不同浓度氧气对兔高空暴露的防护作用

发布时间：2019-04-29 17:12

【摘要】：目的　观察兔暴露于高空时呼吸不同浓度氧气后的生理变化和组织超微结构改变 ,探讨分子筛氧源在高空的防护效果。方法　将 2 0只兔随机分为呼吸空气组 (A)、呼吸 6 3%富氧气体组 (B)、呼吸 83%富氧气体组(C)和呼吸纯氧组 (D)。各组兔在低压舱内上升到 110 0 0m ,停留 30min ,记录心脏区气泡、心电图和客观反应 ,观察心和脑组织超微结构的变化 ,肾组织促红细胞生成素 (EPO)的表达。结果　空气组心脏区气泡数量明显增加 ,多数兔出现心律失常 ;富氧浓度组和纯氧组偶见气泡 ;随着吸入气氧浓度的增加 ,脑、心组织超微结构缺氧改变减轻 ,肾EPOmRNA表达的阳性率降低。结论　呼吸含氧浓度大于 80 %的富氧气体对高空暴露的机体有明显的防护作用。
[Abstract]:Aim to observe the physiological and ultrastructural changes of rabbits exposed to different concentrations of oxygen at high altitude, and to explore the protective effect of molecular sieve oxygen source at high altitude. Methods Twenty rabbits were randomly divided into two groups: breathing air group (A), breathing 63% oxygen enriched gas (B), breathing 83% oxygen enriched gas (C) and breathing pure oxygen (D). The rabbits in each group were raised to 11000 m in hypobaric chamber. 30min was used to record the bubbles in the heart area, ECG and objective reaction. The ultrastructural changes of heart and brain tissue and the expression of erythropoietin (EPO) in renal tissue were observed. Results the number of bubbles in the heart increased significantly in the air group, and arrhythmia occurred in most rabbits, and the bubbles were found occasionally in the oxygen-rich group and pure oxygen group. With the increase of inhaled oxygen concentration, the hypoxia change of brain and heart tissue decreased, and the positive rate of renal EPOmRNA expression decreased. Conclusion the oxygen-rich gas with oxygen concentration greater than 80% has obvious protective effect on the body exposed to high altitude.
【作者单位】：北京空军航空医学研究所北京空军航空医学研究所空军总医院北京空军航空医学研究所北京空军航空医学研究所北京空军航空医学研究所
【基金】：国防科技预研基金资助课题 (编号 99J0 0 2 1 JB2 1 0 2 )
【分类号】：R852.1

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