模拟潜水引起的小型猪骨髓压变化

发布时间：2019-05-13 12:05

【摘要】：目的 :通过测定骨髓压变化 ,评价高气压暴露对骨循环功能的影响。方法 :4头小型猪共进行 6头次 0 4 5MPa压缩空气中暴露 6h后 ,用 1min减压。减压后观察动物发病情况 ,然后在麻醉状态下作股骨中段穿剌并测定 :①骨髓压 ;②向骨髓腔注入生理盐水后的压力恢复速率 (RR) ;③观察泄压后骨髓压重建情况。结果 :动物减压后都出现不同程度的减压病症状 ;测得正常骨髓压为 (12 7± 1 7)mmHg ,RR为 (0 99± 0 0 8)mmHg/min ,泄压后 5 - 10min内骨髓压重建至原先水平。减压后第 1h骨髓压为 (2 7 4± 3 6 )mmHg ,明显高于正常值 (P 0 0 1) ,而第 2h和第 4h无明显改变 ;RR为 (0 6 2± 0 0 5 )mmHg /min ,明显慢于正常值 (P 0 0 1)。结论 :快速减压的模拟潜水使动物骨髓压升高 ,压力恢复时间延迟 ,提示模拟潜水后骨髓血液循环发生障碍 ,可能是减压性骨坏死的发病原因之一。
[Abstract]:Objective: to evaluate the effect of high pressure exposure on bone circulation function by measuring bone marrow pressure. Methods: four miniature pigs were exposed to 0.4 5MPa compressed air for 6 hours and then treated with 1min. After decompression, the incidence of the animal was observed, and then the middle segment of the femur was pierced under anesthesia and measured: (1) bone marrow pressure; (2) pressure recovery rate (RR); after injection of normal saline into the bone marrow cavity. 3 to observe the reconstruction of bone marrow pressure after pressure relief. Results: the symptoms of decompression were observed in all the animals after decompression, and the normal bone marrow pressure was (127 卤17) mmHg, RR) mmHg/min, and the bone marrow pressure in 5-10min was reconstructed to the original level after decompression. The bone marrow pressure (27.4 卤3.6) mmHg,) was significantly higher than the normal value (P 0.01) at 1 h after decompression, but there was no significant change at 2h and 4 h after decompression. RR was (0.62 卤0.05) mmHg / min, which was significantly slower than the normal value (P 0.01). Conclusion: the simulated diving with rapid decompression increases the bone marrow pressure and delays the time of pressure recovery, suggesting that the disturbance of bone marrow blood circulation after simulated diving may be one of the causes of decompression osteonecrosis.
【作者单位】：海军医学研究所海军医学研究所海军医学研究所海军医学研究所海军医学研究所海军医学研究所
【基金】：海军后勤部科学基金资助项目 (No .97- 330 3)
【分类号】：R84

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