评价中西医结合疗法对慢性乙型肝炎ALT、HBeAg和HBV-DNA的影响

发布时间：2017-12-28 17:21

本文关键词：评价中西医结合疗法对慢性乙型肝炎ALT、HBeAg和HBV-DNA的影响　出处：《现代预防医学》2015年08期 　论文类型：期刊论文

更多相关文章： 慢性乙型肝炎 ALT HBeAg HBV-DNA

【摘要】：目的评价中西医结合疗法对慢性乙型肝炎ALT,HBe Ag和HBV-DNA的影响。方法选择2010年4月-2013年6月某院收治的慢性乙型肝炎患者88例作为观察对象。将患者随机分为观察组及对照组,观察组及对照组患者均采用拉米夫定进行抗病毒治疗,观察组在此基础上采用中药进行疏肝解郁、调养肝脾治疗,同时根据患者症状加用不同方剂。比较2组患者治疗24周时、治疗48周时、72周时ALT正常率、HBe Ag转阴率、HBV-DNA转阴率,并评价治疗的安全性。结果观察组与对照组ALT正常率在24周时无差异,但48周及72周时差异有统计学意义,观察组的ALT正常率高于对照组(P0.05);2组间HBe Ag转阴率在各观察时点间均无统计学差异(P0.05);2组HBV-DNA转阴率在24周时无差异,但48周及72周时差异具有统计学意义,观察组的HBV-DNA转阴率高于对照组(P0.05)。治疗过程中2组患者均未出现与药物有关的不良反应,2组患者生命体征、肾功、尿常规、心电图监测结果也较为平稳,未发现患者出现异常改变。结论中西医结合疗法能够提高慢性乙型肝炎ALT的正常率和HBe Ag以及HBV-DNA的转阴率。
[Abstract]:Objective to evaluate the effect of combination of traditional Chinese and Western Medicine on ALT, HBe Ag and HBV-DNA in chronic hepatitis B. Methods 88 cases of chronic hepatitis B patients admitted in a hospital in April 2010 -2013 June were selected as the subjects. The patients were randomly divided into the observation group and the control group. The observation group and the control group were treated with lamivudine, and the observation group was treated with traditional Chinese medicine for relieving liver depression, regulating the liver and spleen, and adding different prescriptions according to the symptoms of the patients. The ALT normal rate, HBe Ag negative rate and HBV-DNA negative rate were compared between the 2 groups at 24 weeks, 48 weeks and 72 weeks, and the safety of the treatment was evaluated. Results the observation group and the control group with normal ALT was no difference at 24 weeks, 48 weeks and 72 weeks were statistically significant in the observation group, the normal rate of ALT is higher than that of control group (P0.05); HBe Ag negative rate between the 2 groups were not statistically different at each observation point between the 2 groups (P0.05); HBV-DNA negative conversion rate had no difference at 24 weeks, but 48 weeks and 72 weeks. The difference was statistically significant in the observation group, the negative rate of HBV-DNA is higher than that of control group (P0.05). During the treatment, there were no drug related adverse reactions in the 2 groups. The vital signs, renal function, urine routine and electrocardiogram monitoring results of the 2 groups were relatively stable, and no abnormal changes were found. Conclusion the combination of traditional Chinese and Western medicine can improve the normal rate of chronic hepatitis B ALT and the negative rate of HBe Ag and HBV-DNA.
【作者单位】：湖北省建始县中医院;湖北省中山医院肝病科;
【分类号】：R512.62
【正文快照】： 慢性乙肝是一种常见的慢性传染性疾病,在全世界范围内广泛流行,根据世界卫生组织报导,全世界约有20亿人感染过HBV病毒。我国是乙型肝炎流行地区[1],据全国HBV感染者血清流行病学调查结果显示,乙肝表面抗原感染率达到9.09%,其中慢性乙型肝炎患者数量约达到3 000万。由于慢性乙

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