中西医结合择时给药治疗Hp相关慢性胃炎的临床研究

发布时间：2018-01-10 11:13

本文关键词：中西医结合择时给药治疗Hp相关慢性胃炎的临床研究　出处：《山东中医药大学》2008年硕士论文　论文类型：学位论文

【摘要】：目的：观察中西医结合并择时给药治疗Hp相关慢性胃炎的疗效,初步探讨中医时间疗法的临床应用。方法：将符合纳入标准的患者随机分为3组,对照组(三联用药),治疗1组(三联用药+加味半夏泻心汤,辰时、戌时服药),治疗2组(三联用药+加味半夏泻心汤,常规时间服药),比较三组患者临床症状缓解率,Hp根除率,停药后随访6个月复发率的差异。结果：临床症状缓解率：对照组有效率74.47%,治疗1组有效率97.87%,治疗2组有效率93.62%。三组比较有显著性差异(p0.05)：两两比较对照组与治疗1组(p0.05)、对照组与治疗2组(p0.05),差异均有统计学意义,但治疗1组与治疗2组比较无统计学意义(p0.05)。 Hp根除率：对照组根除率48.93%,治疗1组根除率82.97%,治疗2组根除率72.34%,三组比较差异有统计学意义(p0.05)。两两比较对照组与治疗1组(p0.05)、对照组与治疗2组(p0.05),差异均有统计学意义,但治疗1组与治疗2组差异无明显统计学意义(p0.05)。停药后6个月随访,观察三组药物远期疗效：三组比较差异有统计学意义(p0.05)；两两比较对照组与治疗1组(p0.05)、对照组与治疗2组(p0.05),差异均有统计学意义,但治疗1组与治疗2组差异无明显统计学意义(p0.05)。结论：中西医结合治疗Hp相关慢性胃炎在改善症状、根除Hp及减少复发等方面优于单纯西药组；中西医结合治疗择时给药与常规时间给药虽无明显统计学差异,但择时给药比常规用药有增强疗效趋势,有待扩大样本量以进一步研究。
[Abstract]:Objective: to observe the therapeutic effect of combination of traditional Chinese and western medicine and timing administration on chronic gastritis associated with HP, and to explore the clinical application of time therapy of traditional Chinese medicine. Methods: the patients who met the inclusion criteria were randomly divided into three groups: the control group (triple drug treatment group, treatment group 1) (triple medication plus Banxia Xiexin decoction, Chen Shi, Xu Shi take medicine). The clinical symptom remission rate and HP eradication rate of the three groups were compared, and the difference of recurrence rate after 6 months follow-up was compared between the three groups (Triple medication plus Banxia Xiexin decoction and routine time). Results: the remission rate of clinical symptoms: the effective rate of control group was 74.47 and the effective rate of treatment group 1 was 97.87%. The effective rate of treatment group 2 was 93.62.There was significant difference among the three groups (p0.05: control group and treatment group 1, control group and treatment group P 0.05). The difference was statistically significant, but there was no significant difference between treatment group 1 and treatment group 2 (P 0.05). Eradication rate of HP: the eradication rate of control group was 48.93, the eradication rate of treatment group was 82.97 and the eradication rate of treatment group was 72.34%. The differences among the three groups were statistically significant (P 0.05). There were significant differences between the control group and the treatment group (P 0.05), the control group and the treatment group (P 0.05). However, there was no significant difference between treatment group 1 and treatment group 2 (P 0.05). After 6 months follow-up, the long-term efficacy of the three groups was observed: there was significant difference between the three groups (P 0.05); There were significant differences between control group and treatment group (P 0.05), control group and treatment group (P 0.05). However, there was no significant difference between treatment group 1 and treatment group 2 (P 0.05). Conclusion: the treatment of HP associated chronic gastritis with integrated Chinese and western medicine is superior to that of western medicine alone in improving symptoms, eradicating HP and reducing recurrence. Although there was no statistical difference between timing and routine administration of combined traditional Chinese and western medicine, there was a tendency to enhance the curative effect of timing administration compared with conventional medicine, so the sample size needed to be expanded for further study.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2008
【分类号】：R573.3

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