中西医治疗原发性肝癌并门静脉癌栓69例临床观察

发布时间：2018-02-13 13:06

本文关键词： 中西医结合介入化疗栓塞门静脉癌栓　出处：《中国现代医学杂志》2008年21期 　论文类型：期刊论文

【摘要】：目的观察超选择性肝段动脉内灌注化疗栓塞、经脾动脉间接门静脉化疗及中药艾迪注射液联合肝素抗凝综合治疗肝细胞癌(HCC)伴门静脉癌栓(PVTT)的疗效。方法138例肝细胞癌合并门静脉癌栓患者随机分为对照组和综合治疗组各69例;分别进行单纯肝动脉内灌注化疗栓塞和超选择性肝段动脉内灌注化疗栓塞、经脾动脉间接门静脉化疗及中药艾迪注射液联合肝素抗凝等治疗。结果综合治疗组有效率完全缓解+缓解(CR+PR)为71.0%(49/69),明显高于对照组40.6%(34/69);综合治疗组1、2、3年生存率分别为81.2%、62.3%和49.3%,中位生存期为17个月,而对照组分别为57.9%、37.3%和27.5%,中位生存期为7个月,两组比较差异有显著性(P0.01),临床受益疗效综合治疗组明显高于对照组(P0.05)。结论该技术能明显提高肝细胞癌合并门静脉癌栓患者近期治疗有效率和生存率,增强机体免疫力,提高生存质量,实为治疗HCC伴PVTT的理想新技术。
[Abstract]:Objective to observe the superselective intraarterial chemoembolization of hepatic segment. Indirect portal vein chemotherapy via splenic artery combined with heparin anticoagulant therapy combined with traditional Chinese medicine Aidi injection in the treatment of hepatocellular carcinoma (HCC) with portal vein thrombus (PVTT). Methods 138 patients with hepatocellular carcinoma complicated with portal vein tumor thrombus were randomly divided into two groups: control group and control group. There were 69 cases in each group. Hepatic arterial infusion chemoembolization and superselective segmental arterial chemoembolization were performed, respectively. Results the effective rate of the comprehensive treatment group was 71.0% 49 / 69%, which was significantly higher than that of the control group (40.6% 34 / 69%), and the survival rate of the combined treatment group was 1 and 3 years, respectively. The median survival time was 17 months. In the control group, 37.3% and 27.5%, the median survival time was 7 months. There was a significant difference between the two groups (P 0.01), and the clinical efficacy of comprehensive treatment group was significantly higher than that of the control group (P 0.05). Conclusion this technique can significantly improve the short-term treatment efficiency and survival rate of patients with hepatocellular carcinoma with portal vein tumor thrombus, and enhance the immunity of the body. Improving the quality of life is an ideal new technique for the treatment of HCC with PVTT.
【作者单位】：河北省邢台市第三医院;
【基金】：河北省自然科学基金(No:0627611057)
【分类号】：R735.7

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