中西医结合治疗对Graves病患者外周血T、B淋巴细胞亚群的影响

发布时间：2018-02-23 16:40

本文关键词： 格雷夫斯病淋巴细胞协同刺激分子中药　出处：《山东大学学报(医学版)》2007年08期 　论文类型：期刊论文

【摘要】：目的:研究中西医结合治疗对Graves病患者外周血T、B淋巴细胞亚群及部分协同刺激分子表达的影响。方法:运用流式细胞术测定20例Graves病初发患者、11例他巴唑治疗患者(西药组)、16例他巴唑合用中药五岳抗甲丸治疗患者(中西医结合组)及16例正常对照外周血淋巴细胞CD19、CD40、CD80、CD3、CD4、CD8、CD28等分子的表达水平。结果:Graves病初发患者CD19+、CD40+、CD19+CD40+、CD80+细胞比率高于正常对照组(P0.01或P0.05),CD3+CD8+细胞比率降低(P0.05),CD3+CD4+/CD3+CD8+比值高于正常对照(P0.05);西药组患者CD80+细胞恢复正常,CD3+CD4+细胞比率及CD3+CD4+/CD3+CD8+比值高于正常对照(P0.05,P0.01),而CD3+CD8+及CD8+CD28+细胞比率低于正常对照(P0.01,P0.05);除CD80+细胞比率高于正常对照外,中西医结合组所测各种分子的表达同正常对照组比较,差异无统计学意义;同西药组比较,中西医结合组CD3+CD4+细胞降低(P0.01),CD3+CD8+及CD8+CD28+细胞比率升高(P0.01,P0.05),CD3+CD4+/CD3+CD8+比值降至正常水平(P0.01)。结论:Graves病患者体液免疫处于较高水平,存在细胞免疫调节失衡,中西医结合治疗较单纯西药治疗更有利于患者免疫状态的恢复。
[Abstract]:Objective: to study the effect of integrated traditional Chinese and western medicine on the expression of Thunb lymphocyte subsets and partial co-stimulatory molecules in peripheral blood of patients with Graves disease. Methods: flow cytometry was used to determine the expression of Thunb lymphocyte subsets and partial costimulatory molecules in peripheral blood of 20 patients with Graves disease. The expression level of CD19, CD40, CD40, CD40, CD80, CD3, CD4, CD8, CD8, CD28, and other molecules in peripheral blood lymphocytes of patients with primary Graves disease were studied. The ratio of P0.01 or P0.05C / CD3 CD8 cells in the western medicine group was higher than that in the normal control group, and the ratio of CD80 cells to normal CD4 cells and CD3 CD4 / CD3 CD8 ratio in the western medicine group was higher than that in the normal control group, while the ratio of CD3 CD8 and CD8 CD28 was higher than that of the normal control group. The percentage of CD80 cells was lower than that of normal controls, except that the ratio of CD80 cells was higher than that of normal controls. Compared with the normal control group, the expression of various molecules measured in the integrated Chinese and western medicine group was not significantly different from that in the western medicine group. The ratio of CD3 CD4 cells and CD8 CD28 cells decreased to a normal level. Conclusion the humoral immunity of patients with CD3's disease is at a higher level, and the cellular immune regulation is out of balance. Integrated Chinese and western medicine treatment is more conducive to the recovery of patients' immune state than western medicine alone.
【作者单位】：山东大学山东省立医院中心实验室山东大学山东省立医院中心实验室山东大学山东省立医院保健科山东大学山东省立医院中心实验室山东大学山东省立医院中心实验室山东大学山东省立医院中心实验室山东大学山东省立医院中心实验室山东大学山东省立医院中心实验室山东大学山东省立医院内分泌科
【基金】：山东省科技厅科技攻关课题(2003-33) 山东省中医药管理局科研基金资助课题(2005-070)
【分类号】：R581.1

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