转化生长因子-β1与高血压肾损害及其中西医防治研究进展

发布时间：2018-03-05 03:33

本文选题：高血压　切入点：转化因子-β　出处：《时珍国医国药》2014年08期 　论文类型：期刊论文

【摘要】：原发性高血压是遗传和环境等因素引起的进行性心血管综合征,是常见的慢性病。其中,肾脏是高血压相关损害的重要靶器官之一,近年来高血压所导致的终末期肾病的发生率呈逐年上升的趋势,国内外实验研究证实,肾损害早期,肾功能可以逆转,因此高血压肾损害早期得到及时防治具有重要意义;中医药在防治高血压肾损害、保护肾功能方面亦发挥重要作用。转化生长因子-β1(transforming growth factor-β1,TGF-β1)作为一种调节细胞的生长、分化、迁移、凋亡及细胞外基质生成的生长因子之一,在高血压肾损害发生、发展及转归中发挥着重要作用。
[Abstract]:Essential hypertension is an advanced cardiovascular syndrome caused by genetic and environmental factors, and is a common chronic disease. Among them, the kidney is one of the important target organs of hypertension related damage. In recent years, the incidence of end-stage nephropathy caused by hypertension is increasing year by year. Experimental studies at home and abroad confirm that renal function can be reversed in the early stage of renal damage. Chinese medicine also plays an important role in preventing and treating hypertensive renal damage and protecting renal function. Transforming growth factor- 尾 1 (TGF- 尾 1) is one of the growth factors that regulate cell growth, differentiation, migration, apoptosis and extracellular matrix production. It plays an important role in the occurrence, development and outcome of hypertensive kidney damage.
【作者单位】：南京中医药大学;江苏省中医院;
【基金】：教育部博士点专项课题项目资助(No.20123237110005) 国家自然基金课题(No.81273713)
【分类号】：R544.11;R692

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