中西医结合治疗雄激素源性脱发临床研究

发布时间：2018-03-05 14:07

本文选题：雄激素源性脱发　切入点：中西医结合　出处：《广州中医药大学》2009年硕士论文　论文类型：学位论文

【摘要】： 研究目的: 探讨以“生发汤”为基础的中药复方结合西药非那雄胺、米诺地尔对雄激素性脱发的治疗效果。研究方法: 本研究为前瞻性研究,采用半随机对照法。本研究选择广州中医药大学第一附属医院皮肤科门诊就诊的男性脱发患者。共92例,分为3组。治疗组40例,予口服“生发汤”(女贞子30g、旱莲草30g、何首乌15g、菟丝子15g、桑寄生15g、丹参30g、田七10g、黄芪30g、茯苓15g,炙甘草10g),结合辨证加减治疗,同时口服非那雄胺;西药对照组25例,予口服非那雄胺;中药对照组27例,予口服“生发汤”(如治疗组)。三组均同时外用米诺地尔。分别观察治疗3个月、6个月后脱发改善及生发情况,及头发油腻、头痒及头屑数量三个伴随症状的改善情况,并记录治疗过程中发生的不良反应。研究结果: 三组患者的年龄、病程和脱发程度比较,均无显著性差异,具有可比性。治疗3个月及6个月后头皮油腻、瘙痒、头屑数量程度改善情况比较,治疗组均明显优于西药对照组,差异具有统计学意义(P＜0.05),而治疗组与中药对照组则改善情况比较接近,差异无统计学意义(P＞0.05),西药对照组改善情况差于中药对照组(P＜0.05)。在临床疗效方面,治疗3个月后治疗组明显优于两对照组,差异有统计学意义(P＜0.05),而西药对照组则优于中药对照组(P＞0.05);经过6个月治疗,治疗组仍然明显优于两对照组,但西药对照组与中药对照组疗效接近(P＞0.05)。治疗组内部,治疗组脱发分型、病程与临床疗效具有相关性(P＞0.05)。三组均未出现性功能减退。治疗组及中药对照组患者经治疗后多诉自觉身体状况明显好转,包括精力较前旺盛,睡眠、饮食等质量明显提高,而西药对照组未见患者有该方面的反馈。中药组有1例(3.70%)使用米诺地尔一周后,出现头皮痒,红,停药2周再继续使用未见不适。研究结论: 研究结果证明,中药治疗雄激素源性脱发疗效确切,安全性好。在起效时间、治疗效果、改善伴随症状方面,治疗组均优于对照组,且随着治疗疗时间延长,治疗效果更为明显增加。说明中西医结合治疗本病比单用西药或中药临床效果更好,既可显著提高患者的生活质量,又可显著提高疗效。
[Abstract]:Objectives of the study:. To explore the therapeutic effect of traditional Chinese medicine prescription combined with western medicine finasteride and minodil on androgen alopecia based on "Shengfa decoction". Research methods:. This study is a prospective study, using a semi-randomized controlled method. In this study, 92 male patients with alopecia were selected from the dermatology department of the first affiliated Hospital of Guangzhou University of traditional Chinese Medicine. They were divided into three groups: treatment group (n = 40), treatment group (n = 40). "Shengfa decoction" (30 g Ligustrum lucidum, 30 g drought lotus grass, 15 g Polygonum multiflorum, 15 g Cuscuta, 15 g mulberry parasitism, 30 g Salvia miltiorrhiza, 10 g Tianqi, 30g Astragalus membranaceus, 15g Poria cocos, 10g grilled licorice 10g) was given orally. The Chinese medicine control group (27 cases) was given orally "Shengfa decoction" (such as the treatment group). All the three groups were treated with minodil at the same time. After 3 months of treatment, 6 months after treatment, the alopecia and hair growth were improved, and the hair was greasy. The three associated symptoms of scalp itching and dandruff quantity were improved and adverse reactions during treatment were recorded. Results of the study:. There was no significant difference in age, course of disease and degree of alopecia among the three groups. After 3 and 6 months of treatment, the degree of greasy scalp, pruritus and quantity of dandruff were improved. The treatment group was significantly better than the western medicine control group, the difference was statistically significant (P < 0.05), while the improvement of the treatment group and the traditional Chinese medicine control group was similar. There was no significant difference (P > 0.05). The improvement of the western medicine control group was worse than that of the traditional Chinese medicine control group (P < 0.05). In the clinical effect, the treatment group was better than the two control groups after 3 months of treatment. The difference was statistically significant (P < 0.05), while that of the western medicine control group was better than that of the traditional Chinese medicine control group (P > 0.05). After 6 months of treatment, the treatment group was still significantly better than the two control groups, but the curative effect between the western medicine control group and the traditional Chinese medicine control group was similar to that of the traditional Chinese medicine control group (P > 0.05). There was a correlation between the course of disease and the clinical curative effect (P > 0.05). After treatment, the patients in the treatment group and the traditional Chinese medicine control group reported that their physical condition was obviously improved, including the improvement of energy, sleep, diet and so on. In the western medicine control group, there was no feedback from the patients. In the Chinese medicine group, one case was treated with minodil for one week, the scalp was itchy, red, and the drug was stopped for 2 weeks. The study concluded that:. The results showed that the treatment of androgen-derived alopecia was effective and safe. The treatment group was superior to the control group in terms of onset time, therapeutic effect and improvement of accompanying symptoms, and the treatment group was superior to the control group in terms of the onset time, the therapeutic effect and the improvement of accompanying symptoms. The therapeutic effect is more obvious. It shows that the combination of traditional Chinese and western medicine is more effective than western medicine or traditional Chinese medicine alone in the treatment of this disease, which can improve the quality of life of the patients and improve the curative effect.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2009
【分类号】：R758.71

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