足三里穴位注射治疗爆发性癌痛的临床观察

发布时间：2018-03-22 05:35

本文选题：穴位注射　切入点：爆发性癌痛　出处：《广州中医药大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的利用疼痛评分指标观察并对比盐酸曲马多注射液穴位注射与肌肉注射在治疗癌痛患者出现爆发性疼痛的临床疗效,为爆发性疼痛患者迅速止痛寻求更有效的具有中医特色的治疗方法。方法采用随机、对照的试验研究方法,将符合纳入标准的60例爆发性疼痛病例按简单随机法分为治疗组与对照组,其中治疗组29例,对照组31例,分别予盐酸曲马多注射液足三里穴位注射和肌肉注射,观察并记录疼痛开始缓解时间、比较不同时间段数字分级法(numerical rating scale,NRS)疼痛评分以及不良反应,初步探讨足三里穴位注射止痛药物在治疗爆发性疼痛患者的临床疗效。结果经治疗后,可看到治疗组的起效时间明显短于对照组。治疗后治疗组及对照组的NRS评分均呈下降趋势,但在治疗后0.5小时两组数值接近,差异无统计学意义(P0.05),在1小时开始两组的NRS评分差异有统计学意义(P0.05),提示随着时间的推移,治疗组的下降趋势与对照组不一致且优于对照组,至治疗后5小时两组的NRS评分均有反弹,但治疗组的NRS评分始终低于对照组,提示足三里穴位注射在维持疗效方面优于肌肉注射。通过观察,两组患者在观察期间出现不良反应的对比差异无统计学意义。结论足三里穴位注射盐酸曲马多注射液相对比肌肉注射在治疗爆发性疼痛具有起效时间更短,更有效缓解疼痛,而没有增加盐酸曲马多注射液的不良反应,是简单易行、安全有效的治疗爆发性癌痛的手段。
[Abstract]:Purpose. The clinical efficacy of tramadol hydrochloride injection at acupoint and intramuscular injection in the treatment of explosive pain in patients with cancer pain was observed and compared with the pain score index. To seek a more effective treatment with TCM characteristics for patients with explosive pain. Method. A randomized, controlled trial was conducted to divide 60 patients with burst pain into treatment group (n = 29) and control group (n = 31) according to the simple randomized method, including 29 cases in treatment group, 31 cases in control group, 31 cases in control group, 29 cases in treatment group and 31 cases in control group. Tramadol hydrochloride injection was given to Zusanli point injection and intramuscular injection to observe and record the onset of pain relief. The pain scores and adverse reactions of numerical rating scale-NRSs in different time periods were compared. To explore the clinical effect of Zusanli acupoint injection analgesic drug in the treatment of explosive pain patients. Results. After treatment, the effective time of the treatment group was significantly shorter than that of the control group. The NRS scores of the treatment group and the control group showed a downward trend after treatment, but the values of the two groups were similar at 0.5 hours after treatment. There was no significant difference in NRS scores between the two groups at 1 hour. It was suggested that the decreasing trend of the treatment group was different from that of the control group and was superior to that of the control group with the passage of time. Up to 5 hours after treatment, the NRS score of both groups rebounded, but the NRS score of the treatment group was always lower than that of the control group, indicating that Zusanli acupoint injection was superior to intramuscular injection in maintaining the curative effect. There was no significant difference in adverse reactions between the two groups. Conclusion. Tramadol hydrochloride injection at Zusanli acupoint has a shorter onset time and more effective pain relief than muscle injection, but it is simple and easy to do without increasing the adverse reactions of tramadol hydrochloride injection. A safe and effective method for the treatment of explosive cancer pain.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R246.5

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