中西医结合治疗急性胰腺炎文献的系统评价与Meta分析

发布时间：2018-03-26 01:33

本文选题：急性胰腺炎　切入点：中药口服　出处：《中华中医药学刊》2017年01期

【摘要】：目的:用循证医学的方法评价中药联合西医常规治疗急性胰腺炎的疗效。方法:检索建库至今中国生物医学文献数据库、CNKI数据库、维普数据库、万方数据库发表的有关中药口服联合西医常规治疗急性胰腺炎疗效的随机对照临床试验相关文献。根据纳入及排除标准,有15项临床试验,1267例AP患者(中药口服治疗组665例,对照组602例)纳入本研究。使用Rev Man 5.2软件合并分析纳入研究的急性胰腺炎患者的有效率、血淀粉酶恢复正常时间、腹痛缓解时间、腹痛持续时间及平均住院天数等结局指标。结果:中药口服联合治疗组的有效率合并效应量RR值为4.35,95%CI为(2.97,6.37),Z=7.56,P0.000 01;χ2=5.70,df=14,P=0.970.05,I2=0%,表明15项的研究资料具有同质性,故采用固定效应模型分析。血淀粉酶恢复正常时间WMD=-2.11,95%CI为(-2.45,-1.76),P0.000 01;腹痛缓解时间WMD=-1.72,95%CI为(-2.18,-1.25),Z=7.26,P0.000 01;患者平均住院天数WMD=-4.53,95%CI为(-5.82,-3.24),Z=6.88,P0.000 01,均明显低于对照组,差异有统计学意义。结论:中药口服联合西医常规治疗能显著缩短急性胰腺炎患者腹痛缓解时间,缩短血淀粉酶恢复正常时间,减少患者平均住院天数,明显提高治疗的有效率。
[Abstract]:Objective: to evaluate the efficacy of traditional Chinese medicine combined with western medicine in the treatment of acute pancreatitis with the method of evidence-based medicine. A randomized controlled clinical trial related to the efficacy of traditional Chinese medicine combined with western medicine in the treatment of acute pancreatitis was published in Wanfang database. According to the criteria of inclusion and exclusion, 15 clinical trials were conducted in 1267 patients with AP (665 cases in the oral Chinese medicine treatment group, 665 cases in the traditional Chinese medicine oral treatment group). Control group (602 cases) were included in this study. The effective rate, serum amylase recovery time, abdominal pain relief time of patients with acute pancreatitis who were included in the study using Rev Man 5.2 software combined with analysis. Results: the RR value of effective rate combined effect was 4.35 卤95 CI = 2.97 卤6.37, P = 0.00001, 蠂 ~ 2 5.70 d ~ (fen) ~ (14) P 0.970.05I ~ (2 0), indicating that 15 items of study data had homogeneity. Therefore, the fixed effect model was used. The CI of WMD-2.1195 CI was -2.45U -1.76 P0.000 01, the remission time of abdominal pain was -2.18 ~ (-1.72N) 95 CI was -2.18 ~ (-1.25) P _ (0.00001), and the average hospitalization days of WMD-4.53 / 9595 / CI was -5.82- 3.240.01, respectively, which was significantly lower than that of the control group, and it was significantly lower than that of the control group (P < 0.05), which was significantly lower than that of the control group (P < 0.05), which was significantly lower than that of the control group (P < 0.05). Conclusion: oral Chinese medicine combined with routine western medicine therapy can significantly shorten the time of abdominal pain relief, shorten the time of serum amylase recovery, and reduce the average hospital stay of patients with acute pancreatitis. The effective rate of treatment was improved obviously.
【作者单位】：辽宁中医药大学;辽宁中医药大学附属医院消化内科;
【基金】：国家中医药管理局中医药标准化项目[SATCM-2015-BZ(040)]
【分类号】：R576

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