中西医结合治疗强直性脊柱炎的临床分析

发布时间：2018-04-01 07:41

本文选题：中西医结合　切入点：强直性脊柱炎　出处：《青岛大学》2017年硕士论文

【摘要】：目的探讨中草药联合西药治疗强直性脊柱炎的临床疗效,为中西医结合治疗强直性脊柱炎提供科学依据。方法选取我院2010年1月至2015年12月期间收住院治疗的76例强直性脊柱炎患者的临床资料进行了回顾性研究,用统计学方法加以分析。根据患者给药治疗方式的差异,将其分为治疗组(n=38)和对照组(n=38)。对照组患者采取西医常规治疗,治疗组患者在西医常规治疗基础上加中医辨证治疗。首先,根据患者的实际病情而定,将其划分为肾阴虚型与肾阳虚型两型,对分别进行针对性的治疗。对照组患者以西医常规行治疗(患者以口服柳氮磺胺吡啶+甲氨蝶呤的形式进行治疗,其中柳氮磺胺吡啶第一周每次用量为1片,用药频率为每日3次,往后以每周递增2片的用量逐次增长,每次用量最多不超过4片;甲氨蝶呤第一周每次用量为2片,用药频率为每周1次,往后用药剂量改为每周3片,用药频率不变。),给予患者以口服的形式进行治疗,治疗组在对照组患者的治疗基础上,另外对对照组患者进行中医辨证治疗。收集治疗前、后患者的BASFI(Bath强直性脊柱炎患者功能指数)、BASDAI(Bath强直性脊柱炎患者病情活动指数)、CRP(超敏C反应蛋白)、ESR(红细胞沉降率)及总有效率等有关指标进行比较,用统计学方法给以分析,从而得出结论。结果研究组和对照组患者的、性别、年龄等基本信息无显著性差异(P0.05),具有可比性。对照组经过治疗后,BASFI、BASDAI、ESR、CRP等指标明显较治疗前好转,治疗组患者的各项指标BASFI、BASDAI、ESR、CRP比对照组患者的指标明显较优,存在明显差异,具有统计学意义(P0.05);治疗组取得的总有效率(94.74%)明显高于对照组(76.32%)。两种治疗方案均有明显临床疗效,治疗组方案更优。结论治疗组患者(中药与西药联合)经治疗后结果,BASFI、BASDAI、ESR、CRP及总有效率等相关指标,均明显优于对照组患者(实施西医治疗)。以中草药联合西药的方法治疗强直性脊柱炎,可缓解病情,有助于改善患者的生活质量。
[Abstract]:Objective to investigate the clinical effect of Chinese herbal medicine combined with western medicine in the treatment of ankylosing spondylitis. Methods the clinical data of 76 patients with ankylosing spondylitis admitted in our hospital from January 2010 to December 2015 were retrospectively studied. According to the difference of the treatment methods, the patients were divided into two groups: the treatment group and the control group. The patients in the control group were treated with routine western medicine, and the patients in the control group were treated with routine western medicine. The patients in the treatment group were treated with TCM syndrome differentiation on the basis of routine western medicine treatment. First of all, according to the actual condition of the patients, they were divided into two types: kidney yin deficiency type and kidney yang deficiency type. The patients in the control group were treated with routine western medicine (the patients were treated with oral salbutamidepyridine methotrexate, in which 1 tablet was used for the first week. The dosage of methotrexate in the first week was 2 tablets each time, the frequency of medication was 1 time per week, and the dosage was changed to 3 tablets per week after the use of methotrexate was 3 tablets per week, the dosage of methotrexate was 3 tablets per week, and the dosage of methotrexate was 3 tablets per week. The treatment group was treated by oral administration. On the basis of the treatment of the patients in the control group, in addition, the patients in the control group were treated with TCM syndrome differentiation. Before the collection and treatment, The functional index of patients with BASFI(Bath ankylosing spondylitis was compared with that of the patients with BASFI(Bath ankylosing spondylitis. The relative indexes such as erythrocyte sedimentation rate (erythrocyte sedimentation rate) and total effective rate of patients with BASFI(Bath ankylosing spondylitis were compared and analyzed by statistical method. Results there was no significant difference in the basic information of sex and age between the study group and the control group (P 0.05), which was comparable. The indexes of ESRCRP in the control group were significantly better than those before treatment, after treatment, there was no significant difference in sex and age between the study group and the control group, and there was no significant difference in the basic information between the study group and the control group (P 0.05). The indexes of the patients in the treatment group were significantly better than those in the control group (P 0.05), and the total effective rate in the treatment group was 94.74% higher than that in the control group (76.32%). Conclusion the results of the treatment group (combination of traditional Chinese medicine and western medicine) after the treatment of the results of the treatment of BASFIX BASDAIK ESRR CRP and the total effective rate and other related indicators, The treatment of ankylosing spondylitis with Chinese herbal medicine combined with western medicine can alleviate the condition and help to improve the quality of life of the patients.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.23

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