基于光谱技术对高血压病不同证型舌象的定量研究

发布时间：2018-04-11 12:11

本文选题：高血压 + 辨证分型　；参考：《广州中医药大学》2013年硕士论文

【摘要】：目的：本研究认为高血压病的证型互相之间的鉴别在舌象上有特定的着手点,而反映在光谱学上有特定的量化指标范围。研究中,我们突出舌诊临床需要,立足中医根本,我们将高血压病证型分为四种,包括痰湿壅盛、阴虚阳亢、肝火亢盛、阴阳两虚,探求他们在光谱上量化的不同,促进中医现代化研究。方法：选取高血压病人213名,中医证型分为痰湿壅盛、肝火亢盛、阴虚阳亢、阴阳两虚四型,采集属于舌尖部位的舌色信息,对不同的证型所采集得到的数据予以计算制图,最后进行统计。采集仪器使用USB4000型VIS/NIR可见近红外光谱仪,Matlab7.0软件(美国MathWorks公司)编程从而进行数据计算,Origin8.0软件(美国Origin Lab公司)制图,均数比较统计分析方面使用的是软件SPSS19.0for Windows。结果：将研究对象舌色的x10与y10值导入到CIE1964标准色度坐标图中,可见各型舌色散点在色度坐标中的分布存在着各自的特点。不同证型的高血压病患者舌色的CIE LAB色空间三维分布区域存在差异。比较高血压病不同证型患者舌色的L值：痰湿壅盛型的舌色的L*值比其余3个证型略高,且与阴虚阳亢型的L*差异有统计学意义(P0.01)；与肝火亢盛型的L*差异有统计学意义(P0.05)；其他证型互相之间差异无统计学意义(P0.05)。通过高血压病不同证型患者舌色a*b*色坐标的分布结果,不同证型的舌色分布差异明显,如痰湿壅盛型主要分布于左方,阴虚阳亢型主要集中在右下方；而肝火亢盛型和阴阳两虚型在图中均分布于图的中上方,其中肝火亢盛型分布偏右,阴阳两虚型分布偏左。不同证型患者舌色色度角存在差异：痰湿壅盛组色度角值最大,阴虚阳亢组色度角值最小,其中阴虚阳亢与痰湿雍盛型之间、阴虚阳亢与阴阳两虚型之间、肝火亢盛与阴阳两虚之间的色度角比较差异有统计学意义(P0.05)；而肝火亢盛与阴虚阳亢型之间、痰湿壅盛与阴阳两虚之间、肝火亢盛与痰湿壅盛之间的色度角比较差异无明显统计学意义(P0.05)。不同证型患者舌色的彩度值差异明显：痰湿壅盛组彩度值最小,阴虚阳亢组彩度值最大,其中阴虚阳亢与痰湿雍盛型之间、阴虚阳亢与阴阳两虚型之间、肝火亢盛与阴阳两虚之间、痰湿壅盛与阴阳两虚之间、肝火亢盛与痰湿壅盛之间的彩度值比较差异有统计学意义(P0.05),而肝火亢盛与阴虚阳亢型之间的彩度值比较差异无明显统计学意义(P0.05)。结论：高血压病四种证型(痰湿壅盛、肝火亢盛、阴虚阳亢、阴阳两虚型)互相之间鉴别时舌色上有差异,而这些差异可以量化反映在光谱数据上面。那么在临床鉴别不同证型时,这些标准量化的光谱数据确可指导辨证。
[Abstract]:Objective:This study suggests that the identification of syndromes of hypertension has a specific starting point in tongue image and a specific quantitative index range in spectroscopy.To promote the study of modernization of traditional Chinese medicine.Methods:Finally, statistics are carried out.Results:By importing the tongue color x10 and y10 values into the CIE1964 standard chromaticity coordinate map, we can see that the distribution of various tongue dispersion points in the chrominance coordinate has its own characteristics.The spatial distribution of CIE LAB color in different syndromes of hypertension patients was different.The L value of tongue color in patients with different syndrome types of hypertension was compared: the L * value of tongue color of phlegm dampness accumulation type was slightly higher than that of the other three syndrome types.There was significant difference between L* and Yin-deficiency and Yang hyperactivity type (P0.01A), and there was significant difference between L* and liver-fire hyperactivity type (P0.05N), and there was no significant difference between other syndrome types (P0.05G).According to the distribution results of the color of tongue in different syndrome types of hypertension, the distribution of tongue color of different syndromes is obvious, such as phlegm and dampness accumulation type mainly distributed on the left side, Yin deficiency and Yang hyperactivity type mainly concentrated in the lower right part;The type of hyperactivity of liver-fire and the deficiency of both yin and yang were distributed in the middle and upper part of the graph, in which the distribution of the hyperactive type of liver-fire was on the right side, and the distribution of the type of deficiency of both yin and yang was on the left.There were differences in tongue color angle between different syndromes: phlegm dampness accumulation group had the largest color angle value, Yin deficiency yang hyperactivity group had the lowest color angle value, among them, Yin deficiency yang hyperactivity and phlegm dampness Yongsheng type, yin deficiency yang hyperactivity and yin yang deficiency type,The difference of color angle between hyperactivity of liver-fire and deficiency of yin and yang was statistically significant (P 0.05), while between hyperactivity of liver fire and hyperactivity of yin and yang, phlegm dampness and deficiency of both yin and yang, there was a significant difference between phlegm and dampness and deficiency of yin and yang.There was no significant difference in chromaticity angle between hyperactivity of liver fire and phlegm dampness.The color values of tongue color of different syndrome types were significantly different: phlegm dampness accumulation group had the smallest color value, and Yin deficiency yang hyperactivity group had the largest color value, in which Yin deficiency yang hyperactivity and phlegm dampness Yongsheng type, yin deficiency yang hyperactivity and yin and yang deficiency type,Between liver-fire hyperactivity and yin and yang deficiency, between phlegm dampness and yin and yang deficiency,There was significant difference in color value between hyperactivity of liver fire and phlegm dampness accumulation, but there was no significant difference in color value between hyperactivity of liver fire and hyperactivity of yin deficiency and yang hyperactivity.Conclusion:There are differences in tongue color between the four syndrome types of hypertension (phlegm dampness hyperactivity, liver fire hyperactivity, yin deficiency and yang hyperactivity, yin and yang deficiency), and these differences can be quantitatively reflected in the spectral data.In clinical identification of different types of syndrome, these standard quantitative spectral data can guide syndrome differentiation.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R241.25;R259

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