胃食管反流病中西医结合治疗及疗效标准研究——附116例临床观察

发布时间：2018-04-16 22:15

本文选题：胃食管反流 + 中西医结合治疗　；参考：《中国中西医结合杂志》2007年03期

【摘要】：目的探讨胃食管反流病(GERD)的中西医结合治疗及疗效标准。方法116例患者随机分两组,分别用中西医结合治疗和单纯西医治疗,并观察治疗前后症状改善、中医症候变化、内镜变化及复发情况。结果总有效率中西医组为84．5%,西药组为67．2%;但停药后两组均复发;中西医组长期疗效优于西药组(P＜0．05),而短期疗效两组比较差异无显著性。中医辨证为虚证和虚实夹杂证比实证易复发(P＜0．05);发病与精神因素相关的患者易复发(P＜0．05);20例靠药物维持一直未停药者,平均服药(10．4±11．4)个月。本病内镜下食管黏膜正常者占69．0%。结论本病基本无治愈,可将“治愈”改为“临床控制”或“显效”,增设“不变”标准。且见食管黏膜破损异常与本病症状表现与转归不统一,故单以内镜积分判断疗效值得商榷。
[Abstract]:Objective to investigate the therapeutic effect of GERD in gastroesophageal reflux disease (GERD).Methods 116 patients were randomly divided into two groups. They were treated with combination of traditional Chinese and western medicine and simple western medicine respectively. The improvement of symptoms, changes of TCM symptoms, changes of endoscopy and recurrence were observed before and after treatment.Results the total effective rate was 84.5 in the traditional Chinese and western medicine group and 67.2 in the western medicine group, but both groups recurred after stopping the treatment, the long-term curative effect of the traditional Chinese and western medicine group was better than that of the western medicine group (P < 0.05), but there was no significant difference between the two groups in the short-term curative effect.The syndrome differentiation of TCM showed that deficiency syndrome and deficiency and deficiency mixed syndrome were more likely to recur than that of positive syndrome (P < 0.05), and 20 cases of patients who had been maintained by drugs for 10. 4 卤11. 4 months had been treated with drugs for 10. 4 卤11. 4 months on average, and 20 patients who were associated with mental factors were prone to relapse (P < 0. 05, P < 0. 05).The percentage of patients with normal esophageal mucosa under endoscope was 69.0.Conclusion there is no cure for this disease, so we can change "cure" to "clinical control" or "remarkable effect" and set up "invariant" standard.It was found that abnormal esophageal mucous membrane damage was not consistent with the symptoms and outcome of the disease, so it was worth discussing to judge the curative effect only by endoscopic integral.
【作者单位】：扬州大学医学院中西医结合研究所扬州大学医学院中西医结合研究所扬州大学医学院中西医结合研究所扬州大学医学院中西医结合研究所
【基金】：江苏省科技厅“十五”重点攻关项目(No．BS2002022)
【分类号】：R571

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