针刀结合手法对膝关节骨性关节炎患者关节液中MMP-3和TIMP-1的影响

发布时间：2018-04-20 16:36

本文选题：膝关节骨性关节炎 + 针刀疗法　；参考：《中国针灸》2010年S1期

【摘要】：目的:探讨针刀结合手法对膝关节骨性关节炎(KOA)患者的作用机制。方法:将100例膝关节骨性关节炎患者随机分为观察组与对照组,每组50例。观察组采用针刀结合手法治疗。对照组采用口服双氯芬酸片治疗。观察两组治疗前后关节液中基质金属蛋白酶-3(MMP-3)及基质金属蛋白酶抑制剂-1(TIMP-1)代谢的变化。结果:治疗后两组关节液中MMP-3、TIMP-1含量均呈下降趋势,与治疗前比较,差异均有统计学意义(P0.01,P0.05)。与对照组比较,观察组下降明显,且接近正常值水平,两组间差异有统计学意义(均P0.05)。结论:针刀结合手法治疗能使膝关节骨性关节炎患者关节液中MMP-3、TIMP-1含量下降,MMPs/TIMPs趋于平衡,从而有可能让软骨退行性变的部分因素得到控制,抑制软骨基质的破坏,从而减轻关节软骨的降解与破坏。这可能是本法治疗KOA的机制之一。
[Abstract]:Objective: to investigate the mechanism of acupuncture-knife combined manipulation in patients with knee osteoarthritis (OA). Methods: 100 cases of knee osteoarthritis were randomly divided into observation group and control group with 50 cases in each group. The observation group was treated with needle knife combined with manipulation. The control group was treated with diclofenac tablets orally. The changes of matrix metalloproteinase-3 (MMP-3) and matrix metalloproteinase inhibitor-1 (TIMP-1) metabolism in articular fluid were observed before and after treatment. Results: the contents of MMP-3 and TIMP-1 in articular fluid of the two groups showed a downward trend after treatment, and the differences were statistically significant compared with those before treatment. Compared with the control group, the observation group decreased obviously, and close to the normal level, the difference between the two groups was statistically significant (P 0.05). Conclusion: needle knife combined with manipulation therapy can decrease the content of MMP-3 and TIMP-1 in articular fluid of patients with osteoarthritis of knee joint and balance MMPs / TIMPs, which may control some factors of cartilage degeneration and inhibit the destruction of cartilage matrix. So as to reduce the degradation and destruction of articular cartilage. This may be one of the mechanisms of this method in the treatment of KOA.
【作者单位】：湖北丹江口市中医院;
【分类号】：R246;R274.9

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