中西医结合治疗脑梗死后继发癫痫的临床疗效分析

发布时间：2018-05-05 20:25

本文选题：天麻素 + 卡马西平　；参考：《辽宁中医杂志》2017年09期

【摘要】：目的:探讨天麻素联合卡马西平治疗脑梗死后继发癫痫的临床疗效。方法:选取2011年4月—2016年9月该院收治的脑梗死后继发癫痫的患者86例为研究对象,采用随机数字表法分为治疗组与对照组,对照组患者给予卡马西平治疗,治疗组患者给予天麻素联合卡马西平治疗的基础上加用中医辨证治疗,对比两组患者的临床疗效、脑电图改善情况,在治疗前后检测患者白细胞介素-1β(IL-1β)、D-二聚体(D-D)及肿瘤坏死因子-α(TNF-α)的水平变化,并观察两组患者不良反应发生情况。结果:治疗组与对照组的总有效率分别为93.02%、76.74%,两组相比,治疗组总有效率明显升高(P0.05);治疗组与对照组脑电图改善率分别为90.70%、81.39%,两组相比,治疗组脑电图改善率明显升高(P0.05);与治疗前对比,治疗后治疗组与对照组患者的IL-1β、D-D、TNF-α水平均明显降低(P0.05),且治疗组患者IL-1β、D-D、TNF-α水平改善程度优于对照组(P0.05);治疗组与对照组的不良反应发生率分别11.63%、13.95%,两组不良反应发生率对比无显著差异(P0.05)。结论:天麻素联合卡西马平治疗的基础上加用中医辨证治疗脑梗后继发癫痫可显著提高临床疗效,改善脑电图状况,值得推广应用。
[Abstract]:Objective: to investigate the clinical effect of Gastrodin combined with carbamazepine in the treatment of secondary epilepsy after cerebral infarction. Methods: 86 patients with secondary epilepsy after cerebral infarction were selected from April 2011 to September 2016. The patients were randomly divided into two groups: treatment group and control group. Patients in control group were treated with carbamazepine. The patients in the treatment group were treated with Gastrodin combined with carbamazepine plus TCM syndrome differentiation. The clinical efficacy and the improvement of EEG were compared between the two groups. Before and after treatment, the levels of IL-1- 尾 -IL-1 尾 -D-dimer and tumor necrosis factor- 伪 (TNF- 伪) were detected, and the adverse reactions of the two groups were observed. Results: the total effective rates of the treatment group and the control group were 93.02 and 76.74, respectively. Compared with the two groups, the total effective rate of the treatment group was significantly higher than that of the control group, and the improvement rate of EEG in the treatment group and the control group was 90.70 and 81.39, respectively. The improvement rate of EEG in treatment group was significantly higher than that before treatment. After treatment, the levels of IL-1 尾 -D-DnTNF- 伪 in the treatment group and the control group were significantly lower than those in the control group, and the improvement degree of the IL-1 尾 -D-DNF- 伪 level in the treatment group was better than that in the control group, and the incidence of adverse reactions in the treatment group and the control group was 11.63 ~ 13.95, respectively. There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: on the basis of Gastrodin combined with Cassemapine therapy combined with TCM syndrome differentiation in the treatment of secondary epilepsy after cerebral infarction can significantly improve the clinical efficacy and improve the state of electroencephalogram which is worth popularizing.
【作者单位】：云南省第一人民医院神经内科;
【基金】：云南省卫生科技计划项目(2016NS223)
【分类号】：R742.1;R743.33

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