中西医联合治疗眼底出血随机对照试验的Meta分析

发布时间：2018-05-06 17:40

本文选题：眼出血 + 中西医结合疗法　；参考：《中国全科医学》2017年S2期

【摘要】：目的评价中西医联合治疗眼底出血的有效性和安全性。方法计算机检索Pub Med、Cochrane Library、中国知网、维普网、中国生物医学文献数据库、万方数据知识服务平台中收录的有关中西医联合治疗与西医治疗眼底出血的中、英文文献,手工检索相关的参考文献,检索时间为建库至2017年4月。纳入比较中西医联合治疗与西医治疗眼底出血的随机对照试验。采用Cochrane系统评价手册评估文献质量;采用Review Manager 5.3软件对临床疗效进行Meta分析。结果共纳入16篇文献,共1 821只眼(中西医联合治疗眼底出血组925只眼,西医治疗眼底出血组896只眼),均为随机对照试验。Meta分析结果显示,中西医联合治疗眼底出血组的临床疗效好于西医治疗眼底出血组,差异有统计学意义[WMD=3.58,Z=9.38,95%CI(2.74,4.67),P0.001]。临床疗效倒漏斗图相对对称,提示发表偏倚较小。结论中西医联合治疗眼底出血的临床疗效优于西医治疗眼底出血。所纳入的部分文献中未记录随机分组的方法和具体药物使用情况,所以文献的总体质量不高,仍需大量高质量的随机对照试验来证实中西医联合治疗眼底出血的有效性。但中西医联合治疗给眼底出血的患者带来了新希望。在临床实践中将中医的辨证论治与西医治疗眼底出血更完美的结合,给患者的预后带来更好的长期疗效。
[Abstract]:Objective to evaluate the efficacy and safety of combined traditional Chinese and western medicine in the treatment of fundus hemorrhage. Methods the Chinese and English literatures on the treatment of ocular fundus hemorrhage were searched by computer in Pub Medsite Cochrane Library, China knowledge Network, Weip Web, Chinese Biomedical Literature Database and Wanfang data knowledge Service platform. Manual retrieval of relevant references, retrieval time for the establishment of the database until April 2017. A randomized controlled trial was conducted to compare the combined treatment of traditional Chinese and western medicine with that of western medicine in the treatment of ocular fundus hemorrhage. The literature quality was evaluated by Cochrane system evaluation manual and Meta analysis was performed by Review Manager 5.3 software. Results A total of 1 821 eyes (925 eyes in the fundus hemorrhage group treated with traditional Chinese and western medicine and 896 eyes in the fundus hemorrhage group treated with western medicine) were included in 16 articles. The clinical effect of combined TCM and Western medicine in treating fundus hemorrhage group was better than that in western medicine group, and the difference was statistically significant. The clinical efficacy of inverted funnel graph is relatively symmetrical, suggesting that the publication bias is small. Conclusion the therapeutic effect of combined traditional Chinese and western medicine on fundus hemorrhage is better than that on western medicine. The method of random grouping and the use of specific drugs were not recorded in part of the literature, so the overall quality of the literature is not high, and a large number of high quality randomized controlled trials are still needed to confirm the effectiveness of combined TCM and Western medicine in the treatment of fundus hemorrhage. But the combined treatment of traditional Chinese and western medicine brings new hope to the patients with fundus hemorrhage. In clinical practice, the combination of TCM syndrome differentiation and western medicine in the treatment of ocular fundus hemorrhage is more perfect, which will bring better long-term curative effect to the prognosis of patients.
【作者单位】：浙江省宁波市鄞州人民医院眼科中心;
【基金】：基金项目:加味温胆汤联合玻璃体腔内注射康柏西普注射液治疗湿性老年性黄斑变性的临床研究(2017ZB083)
【分类号】：R774.1

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