中西医个体化分层治疗老年急性髓系白血病回顾性分析

发布时间：2018-05-11 16:33

  本文选题：老年急性髓系白血病 + 中西医结合　； 参考：《中国中西医结合杂志》2017年09期

【摘要】：目的回顾性分析中西医个体化分层治疗老年急性髓系白血病(AML)的临床疗效和不良反应。方法采用回顾性研究方法,根据患者合并的基础疾病、体力状态(ECOG)评分、治疗方法将54例老年AML患者分为A组(扶正祛邪方加减+标准剂量化疗组,19例)、B组(扶正祛邪方加减+减低剂量化疗组,18例)、C组(扶正祛邪方加减姑息治疗组,17例),分析患者骨髓缓解率、生存时间、中医证候疗效和不良反应。结果54例患者缓解率为68.5%(37/54),平均生存时间为(12.9±6.0)个月,中位生存时间为13个月,1年及以上生存率为55.6%(30/54),中医证候总有效率为83.3%(45/54),患者出现感染、胃肠道反应、心脏毒性、肝肾毒性的发生率分别为25.9%(14/54)、16.7%(9/54)、11.1%(6/54)、7.4%(4/54)。除中医证候疗效外,C组其余指标均低于A、B组(P0.05)。结论中西医个体化分层方案可提高老年AML临床疗效,减少不良反应的发生,提高生存质量,增加远期疗效。
[Abstract]:Objective to analyze the clinical efficacy and adverse effects of individualized stratification of traditional Chinese and western medicine in the treatment of elderly patients with acute myeloid leukemia (AML). Methods A retrospective study was conducted to evaluate the patients' underlying diseases, physical status and ECOG scores. 54 elderly patients with AML were divided into two groups: group A (Fuzheng Quxie decoction plus or minus standard dose chemotherapy group, n = 19 cases, group B) (group A, n = 18) with Fuzheng Quxie decoction plus or minus reducing dose chemotherapy group, group C (Fuzheng Quxie decoction plus or minus palliative treatment group, n = 18, n = 18). Analysis of bone marrow remission rate, Survival time, TCM syndrome efficacy and adverse reactions. Results the remission rate of 54 patients was 68.5% 37 / 54, the average survival time was 12.9 卤6.0 months, the median survival time was 13 months, the survival rate of one year and more was 55.60.54%, the total effective rate of TCM syndrome was 83.30.45r54%, the patients had infection, gastrointestinal reaction, cardiac toxicity. The incidence of hepatorenal toxicity was 25. 9 / 14 / 54 / 16. 7 / 11. 6 / 54 / 7. 4 / 54. The other indexes of group C were lower than that of group A B (P 0.05) except the curative effect of TCM syndromes. Conclusion individualized stratification of traditional Chinese and western medicine can improve the clinical efficacy of AML, reduce the occurrence of adverse reactions, improve the quality of life, and increase the long-term efficacy.
【作者单位】： 天津中医药大学第一附属医院血液科;天津中医药大学研究生院;
【基金】：天津市应用基础及前沿技术研究计划重点资助项目(No.12JCZDJC25400)
【分类号】：R733.71
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本文编号：1874715