中西医结合治疗慢性阻塞性肺疾病急性加重期痰瘀阻肺证临床疗效及对炎性细胞因子、NF-κB的影响

发布时间：2018-05-16 20:18

  本文选题：中医药 + AECOPD　； 参考：《中华中医药学刊》2017年10期

【摘要】：目的:探讨清肺活血中药辅助舒利迭治疗慢性阻塞性肺疾病急性加重期(AECOPD)痰瘀阻肺证临床疗效及对炎性细胞因子、NF-κB的影响。方法:研究对象选取医院2015年2月—2017年2月收治AECOPD痰瘀阻肺证患者共100例,随机分为对照组(50例)和观察组(50例),分别给予舒利迭单用治疗和在此基础上加用清肺活血中药辅助治疗,比较两组患者临床疗效,治疗前后主要证候积分、肺功能指标、血气分析指标、炎性细胞因子及NF-κB水平等。结果:观察组患者治疗总有效率显著高于对照组(P0.05);观察组患者治疗后主要证候积分显著低于对照组、治疗前(P0.05);观察组患者治疗后FEV1预计值、FEV1/FVC、PaO_2、PaCO_2及SaO_2水平均显著优于对照组、治疗前(P0.05);观察组患儿治疗后hs-CRP、IL-10、TNF-α及NF-κB水平均显著优于对照组、治疗前(P0.05)。结论:清肺活血中药辅助舒利迭治疗AECOPD痰瘀阻肺证可有效减轻相关症状体征,提高肺部通气功能,改善动脉血气指标,抑制机体炎症反应,并有助于调节NF-κB水平。
[Abstract]:Objective: to investigate the clinical effect of Qingfei Huoxue traditional Chinese medicine (TCM) for treating chronic obstructive pulmonary disease (COPD) with acute exacerbation of chronic obstructive pulmonary disease (COPD) with phlegm and stasis and its effect on inflammatory cytokine NF- 魏 B. Methods: from February 2015 to February 2017, 100 patients with AECOPD syndrome of phlegm and stasis were selected. Two groups were randomly divided into two groups: control group (n = 50) and observation group (n = 50). The patients in the observation group were treated with sulidil alone and supplemented with traditional Chinese medicine for clearing the lung and activating blood on this basis. The clinical efficacy, the main syndromes integral, the pulmonary function index before and after treatment were compared between the two groups. Blood gas analysis, inflammatory cytokines and NF- 魏 B levels. Results: the total effective rate of treatment in the observation group was significantly higher than that in the control group (P 0.05), the score of the main syndromes in the observation group was significantly lower than that in the control group (P 0.05), the predicted value of FEV1 in the observation group was significantly higher than that in the control group (P < 0.05), and the predicted value of FEV1 in the observation group was significantly higher than that in the control group (P < 0.05). The levels of hs-CRPnIL-10 TNF- 伪 and NF- 魏 B in the observation group were significantly higher than those in the control group (P 0.05). Conclusion: Chinese herbal medicine for clearing lung and activating blood circulation can effectively relieve the symptoms and signs of phlegm stasis in AECOPD, improve pulmonary ventilation function, improve arterial blood gas index, inhibit inflammatory reaction, and help to regulate the level of NF- 魏 B.
【作者单位】： 青岛市海慈医疗集团肺病科;
【基金】：青岛市公共领域科技支撑计划项目[11-2-3-4(4)-nsh]
【分类号】：R563.9
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本文编号：1898255