中西医结合治疗急性一氧化碳中毒疗效观察及与血浆磷脂酸的相关性研究

发布时间：2018-05-17 14:08

  本文选题：急性一氧化碳中毒 + 迟发性脑病　； 参考：《辽宁中医杂志》2008年07期

【摘要】：目的:研究急性一氧化碳中毒患者血浆溶血磷脂酸变化与病情严重程度的相关性,血浆溶血磷脂酸水平对急性一氧化碳中毒患者发生迟发型脑病的预警作用,探讨对血浆溶血磷脂酸升高早期干预防止迟发型脑病的可行性。方法:204例急性一氧化碳中毒患者,入院后分为轻、中、重度中毒,均于入院后24h内采集静脉血测定血浆溶血磷脂酸,观察血浆溶血磷脂酸水平与病情严重程度的关系。随访至发病后60天,观察不同血浆溶血磷脂酸水平发生迟发性脑病的比例。对血浆溶血磷脂酸升高者随机分为观察Ⅰ组、观察Ⅱ组,观察Ⅱ组采用常规治疗,观察Ⅰ组加奥扎格雷、醒脑静静脉点滴,对比两组发生迟发性脑病的比例。结果:(1)急性一氧化碳中毒患者轻度中毒血浆溶血磷脂酸无明显变化,中度中毒血浆溶血磷脂酸轻中度升高,重度中毒明显升高,组间有显著差异;(2)血浆溶血磷脂酸正常者无迟发性脑病发生,轻度异常者1例发生迟发性脑病,中度异常者无迟发性脑病,重度中毒者21例发生迟发性脑病。组间有显著差异;(3)对血浆溶血磷脂酸升高者121例分为两组,观察Ⅰ组发生迟发性脑病6例,观察Ⅱ组发生迟发性脑病20例,组间有显著差异。结论:急性一氧化碳中毒中重度患者存在血栓前状态,血浆溶血磷脂酸升高与病情严重程度呈正相关,可作为判断急性中毒患者病情严重程度的指标,血浆溶血磷脂酸升高程度与发生迟发性脑病的危险性呈正相关,可作为发生迟发性脑病的预警标记物。对血浆溶血磷脂酸升高者早期干预可明显减少迟发性脑病的发生。
[Abstract]:Objective: to study the relationship between the changes of plasma lysophosphatidic acid and the severity of acute carbon monoxide poisoning, and the early warning effect of plasma lysophosphatidic acid level on delayed encephalopathy in patients with acute carbon monoxide poisoning. To explore the feasibility of early intervention on plasma lysophosphatidic acid elevation to prevent delayed encephalopathy. Methods 204 patients with acute carbon monoxide poisoning were divided into mild, moderate and severe poisoning. Venous blood samples were collected within 24 hours after admission for determination of plasma lysophosphatidic acid, and the relationship between plasma lysophosphatidic acid level and severity of the disease was observed. The rate of delayed encephalopathy in different plasma lysophosphatidic acid levels was observed after 60 days follow-up. Patients with elevated plasma lysophosphatidic acid were randomly divided into observation group 鈪，

本文编号：1901675