电针结合中频对腰神经根受压模型大鼠抗炎镇痛的作用

发布时间：2018-05-24 17:30

本文选题：腰神经根受压 + 模型　；参考：《中国针灸》2011年08期

【摘要】：目的:探讨电针结合中频治疗腰神经根受压的效应及作用机制。方法:将72只SD大鼠随机分为正常组、假手术组、模型组、电针组、中频组和电针加中频组,每组12只。后4组经手术复制腰神经根受压模型。正常组、假手术组、模型组不做任何治疗,电针组进行电针治疗,穴取"夹脊""环跳"等,中频组采用中频治疗,穴取"夹脊""环跳",电针加中频组先后进行电针与中频治疗,取穴及治疗时间与上两组相同。所有治疗均于造模成功后第5天开始,每日1次,连续治疗14 d。观察治疗前后大鼠患肢大体观,检测治疗后血浆血栓素B 2(TXB 2)、前列环素F1α(PGF1α)含量,并通过光镜观察受压神经根局部的病理变化。结果:与治疗前相比,3个治疗组均能明显降低模型大鼠患肢神经功能评分(均P0.01)。治疗后,与模型组相比,电针组及电针加中频组TXB 2下降明显(均P0.01),电针加中频组PGF1α上升明显(P0.01),3组的TXB 2/PGF1α比值均得到了良性调整(均P0.01),同时电针组、电针加中频组的病理评分改善明显(均P0.01)。结论:电针结合中频治疗对腰神经根受压模型大鼠具有抗炎镇痛的作用;降低TXB 2、升高PGF1α、维持两者的动态平衡,从而改善微循环状态是其作用机制之一。
[Abstract]:Objective: to investigate the effect and mechanism of electroacupuncture combined with middle frequency in the treatment of lumbar nerve root compression. Methods: Seventy-two SD rats were randomly divided into normal group, sham operation group, model group, electroacupuncture group, intermediate frequency group and electroacupuncture plus intermediate frequency group with 12 rats in each group. The model of lumbar nerve root compression was established by operation in the latter 4 groups. The normal group, sham-operation group and model group did not do any treatment. The electroacupuncture group was treated with electroacupuncture, the acupoints were treated with "clip ridge" and "loop jump", the intermediate frequency group was treated with intermediate frequency therapy, the point was treated with "clip ridge" and "loop jump", and the electroacupuncture plus intermediate frequency group was successively treated with electroacupuncture and intermediate frequency. The acupoints and treatment time were the same as those in the above two groups. All the patients were treated continuously for 14 days on the 5th day after successful modeling. After treatment, the contents of thromboxane B 2(TXB 2, prostacyclin F 1 伪 and PGF 1 伪 were observed, and the pathological changes of compressed nerve roots were observed by light microscope. Results: compared with before treatment, the neurological function scores of the affected limbs of the model rats were significantly decreased in the three treatment groups (all P 0.01). After treatment, compared with the model group, TXB _ 2 decreased significantly in the electroacupuncture group and the electroacupuncture plus intermediate frequency group (all P 0.01). The ratio of TXB 2/PGF1 伪 in the electroacupuncture plus intermediate frequency group was significantly increased (P 0.01) and the TXB 2/PGF1 伪 ratio in the electroacupuncture plus medium frequency group was significantly adjusted (P 0.01), while in the electroacupuncture group, there was no significant difference between the two groups. The pathological score of electroacupuncture plus intermediate frequency group was improved obviously (all P 0.01). Conclusion: electroacupuncture combined with middle frequency therapy has anti-inflammatory and analgesic effect on lumbar nerve root compression model, and decreasing TXB _ 2, increasing PGF1 伪, maintaining dynamic balance between them and improving microcirculation is one of its mechanisms.
【作者单位】：东南大学附属中大医院针灸科;江苏省中医院针灸科;
【基金】：江苏省中医药管理局课题资助项目:HZ07023
【分类号】：R245

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