基于脑电的磁刺激穴位复杂脑功能网络研究

发布时间：2018-05-30 12:46

本文选题：穴位 + 磁刺激　；参考：《河北工业大学》2013年博士论文

【摘要】：穴位是体表刺激到体内神经系统调控的切入点，，磁刺激技术因具有诸多不可比拟的优势而有望成为一种穴位新疗法，但是目前磁刺激穴位的疗效缺乏统一且合理的评定方法，还需进行深入探究。脑连接组学研究的逐步深入和复杂网络理论的飞速发展为磁刺激穴位的研究开辟了新途径。本文利用复杂网络分析方法，以内关穴为例开展了基于高时间分辨率脑电的磁刺激穴位脑功能网络的构建与分析研究，旨在从整体性角度探索磁刺激穴位对大脑功能连接的影响，为穴位磁刺激的作用效应评价提供新手段，尤其为精神类等疾病的临床康复治疗效果评价提供新思路。本文主要研究内容如下： 1、设计并开展了不同频率磁刺激穴位和非穴位不同阶段的脑电采集实验，采用互相关和互信息方法对不同状态下高分辨率的脑电信号进行了多通道关联特性分析，结果发现3Hz磁刺激内关穴时脑功能连接增强的趋势较为明显。 2、基于磁刺激穴位的多通道脑电信号关联特性矩阵构建了无权和加权脑功能网络，并对网络特征量进行了深入分析，结果发现3Hz磁刺激内关穴时脑功能网络连接边、平均度、平均聚类系数和全局效率显著增加，平均路径长度显著降低。磁刺激非穴位时脑功能网络特征量的变化明显小于穴位刺激引起的变化。 3、对磁刺激穴位的无权和加权脑功能网络进行了中心度和中心化程度分析，结果发现3Hz磁刺激内关穴时额叶、中央区以及顶叶大部分节点的度中心度和紧密中心度明显升高，顶叶和中央区部分节点的介数中心度明显减小。磁刺激非穴位时脑功能网络中心度的变化明显小于穴位刺激引起的变化。 4、对磁刺激穴位的脑功能网络进行了“小世界”属性评价，结果发现所有被试不同刺激阶段的脑功能网络均具有“小世界”属性，3Hz磁刺激内关穴时脑功能网络的“小世界”属性显著增强。磁刺激非穴位时脑功能网络“小世界”属性的变化小于穴位刺激引起的变化。
[Abstract]:Acupoint is the cut-in point from body surface stimulation to internal nervous system regulation. Magnetic stimulation technology is expected to become a new therapy for acupoints because of its incomparable advantages. However, at present, there is no uniform and reasonable evaluation method for the effect of magnetic stimulation on acupoints. Further research is needed. The rapid development of the theory of complex network and the study of brain connectionology have opened up a new way for the study of magnetic stimulation acupoints. In this paper, using the complex network analysis method, taking Neiguan point as an example, the construction and analysis of the functional network of magnetic stimulation acupoint based on high-resolution EEG are carried out. The purpose of this study is to explore the effect of magnetic stimulation on the functional connections of the brain from a holistic point of view, and to provide a new method for the evaluation of the effect of magnetic stimulation at acupoints, especially for the evaluation of the effect of clinical rehabilitation therapy for mental diseases. The main contents of this paper are as follows: 1. The EEG sampling experiments of different frequency magnetic stimulation points and non-acupoints were designed and carried out. The multi-channel correlation characteristics of high-resolution EEG signals in different states were analyzed by cross-correlation and mutual information methods. The results showed that 3Hz magnetic stimulation of Neiguan point showed an obvious tendency of enhancement of brain functional connections. 2. Based on the multi-channel EEG correlation characteristic matrix of magnetic stimulation acupoints, the weighted and unweighted brain function network was constructed, and the characteristic quantity of the network was analyzed in depth. The results showed that the brain function network connected edge and average degree when 3Hz magnetic stimulation at Neiguan point. The average clustering coefficient and global efficiency increased significantly, and the average path length decreased significantly. The change of the characteristic quantity of brain function network in magnetic stimulation was obviously smaller than that caused by acupoint stimulation. 3. The degree of centrality and centralization of weighted and unweighted brain function network of magnetic stimulation acupoints were analyzed. The results showed that the degree of centrality and dense centrality of frontal lobe, central region and most nodes of parietal lobe were significantly increased by 3Hz magnetic stimulation at Neiguan point. The centroid of some nodes in parietal lobe and central region decreased obviously. The change of cerebral functional network centrality in magnetic stimulation was significantly smaller than that induced by acupoint stimulation. 4. The "small world" attribute of the brain function network of magnetic stimulation acupoints was evaluated. The results showed that all the brain functional networks at different stimulation stages had the "small world" attribute. The "small world" attribute of the brain functional network was significantly enhanced when the Neiguan acupoint was stimulated with 3Hz magnetic stimulation. The change of the "small world" attribute of brain function network is smaller than that caused by acupoint stimulation when magnetic stimulation is non-acupoint.
【学位授予单位】：河北工业大学
【学位级别】：博士
【学位授予年份】：2013
【分类号】：R245

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