中西医结合治疗系统性红斑狼疮疗效观察

发布时间：2018-06-07 02:21

本文选题：系统性红斑狼疮 + 中西医结合　；参考：《中国中西医结合杂志》2008年11期

【摘要】：目的观察中西医结合治疗系统性红斑狼疮的疗效。方法110例系统性红斑狼疮患者随机分为两组,对照组(50例)口服泼尼松,治疗组(60例)在对照组治疗的基础上,按中医辨证分3型(3期)施治,疗程6个月。观察两组治疗前后临床症状、免疫学指标、血象、血沉(ESR)、C反应蛋白(CRP)、血肌酐(SCr)及24h尿蛋白定量(u-TP/24h)的变化。结果治疗组临床缓解29例,显效18例,有效9例,无效4例,总有效率93.3%(56/60);对照组临床缓解11例,显效10例,有效19例,无效10例,总有效率80.0%(40/50),两组总有效率比较,差异有统计学意义(χ2=4.36,P0.05)。治疗组临床症状中发热、关节痛、脱发改善优于对照组(P0.05,P0.01,P0.05);治疗组抗核抗体(ANA)转阴率51.3%(20/39)、抗双链脱氧核糖核酸抗体(抗ds-DNA)转阴率53.6%(15/28)、抗核糖核蛋白抗体(抗RNP)转阴率63.2%(12/19)、循环免疫复合物(CIC)转阴率63.2%(12/19),对照组分别依次为28.1%(9/32)、26.1%(6/23)、29.4%(5/17)、29.4%(5/17),治疗组皆优于对照组(P0.05);两组免疫球蛋白(IgG、IgM)治疗后均下降,且治疗组优于对照组(P0.05,P0.01);两组血象、ESR、CRP、SCr及u-TP/24h均改善,且治疗组优于对照组(P0.05,P0.01)。结论中西医结合治疗系统性红斑狼疮疗效显著。
[Abstract]:Objective to observe the efficacy of integrated traditional Chinese and western medicine in the treatment of systemic lupus erythematosus. Methods 110 patients with systemic lupus erythematosus were randomly divided into two groups: control group (n = 50) and prednisone group (n = 60). The changes of clinical symptoms, immunological parameters, erythrography, erythrocyte sedimentation rate (ESR) C-reactive protein (CRP), serum creatinine (SCR) and 24 h urine protein (24 h) were observed. Results in the treatment group, there were 29 cases of clinical remission, 18 cases of remarkable effect, 9 cases of effective, 4 cases of ineffectiveness, and a total effective rate of 93.3% 56 / 60, while the control group had 11 cases of clinical remission, 10 cases of remarkable effect, 19 cases of effective and 10 cases of failure, and the total effective rate of 80.0% 40 / 50%, the total effective rate was compared between the two groups. The difference was statistically significant (蠂 2, 4.36, P 0.05). In the treatment group, fever and joint pain were found in clinical symptoms. The improvement of alopecia was better than that of the control group (P 0.05, P 0.01, P 0.05), the negative rate of anti-nuclear antibody Ana was 51.33% 2039, the negative rate of anti-ds-DNA was 53.6%, the negative rate of anti-RNP was 63.21219%, the negative rate of circulating immune complex was 1219%, the negative rate of anti-ds-DNA was 53.6%, the negative rate of anti-RNP was 63.21219%. The order of 28. 1 / 32 / 26. 1 was 28. 1 / 32 / 26. 6 / 23 / 29. 4% 5 / 17 and 29. 4% respectively. The treatment group was better than the control group (P 0. 05%). After treatment, the immunoglobulin (IgG) IgM decreased in both groups. The results showed that the treatment group was superior to the control group (P 0.05) and the control group was better than the control group (P 0.05 P 0.01), and the two groups had improved both the u-TP/24h and the CRP SCR, and the treatment group was superior to the control group (P 0.05 P 0.01). Conclusion the therapeutic effect of integrated traditional Chinese and western medicine on systemic lupus erythematosus is remarkable.
【作者单位】：浙江省杭州市下沙医院;山东省济宁市中医院;山东省济宁市第一人民医院;
【分类号】：R593.241

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