中西医临床免疫治疗口腔扁平苔藓的临床研究

发布时间：2018-06-12 23:06

本文选题：口腔扁平苔藓 + 中西医结合　；参考：《实用口腔医学杂志》2010年04期

【摘要】：目的:观察中西医临床免疫治疗口腔扁平苔藓的疗效。方法:40例口腔扁平苔藓患者随机分为2组,中西医结合临床免疫治疗组(中西组)20例,单纯西药组(西组)20例,分别采用中西医临床免疫治疗和单纯西药疗法,8周后观察近期疗效,1年后观察远期疗效,并测定治疗前后IL-8、TNF-α、IL-6水平,观察患者免疫功能变化情况。结果:近期疗效:中西组显效率90.00%,总有效率95.00%;西组显效率10%,总有效率50%。中西组疗效显著高于西组(P0.01)。远期疗效:中西组总有效率94.30%,西组总有效率35.3%,P0.01。与正常对照组比较2组IL-8、TNF-α、IL-6均升高(P0.01),中西组治疗后IL-8较治疗前明显降低(P0.01),TNF-α、IL-6治疗后较治疗前降低(P0.05)。西组治疗后IL-8、TNF-α、IL-6较治疗前降低(P0.05),2组治疗后IL-8比较,P0.01,TNF-α、IL-6比较,P0.05,差异有显著性。结论:中西医临床免疫治疗口腔扁平苔藓疗效高、疗程短、复发率低、无明显副作用,能快速有效地改善口腔扁平苔藓患者免疫功能,值得临床广泛应用。
[Abstract]:Objective: to observe the efficacy of traditional Chinese and western medicine in the treatment of oral lichen planus. Methods 40 patients with oral lichen planus were randomly divided into two groups: 20 cases in Chinese and western medicine group, 20 cases in western medicine group and 20 cases in western medicine group. The short-term and long-term effects were observed after 8 weeks and 1 year, respectively. The level of IL-8 TNF- 伪 and IL-6 were measured before and after treatment, and the changes of immune function were observed. Results: the short-term curative effect: the effective rate of the Chinese and western groups was 90.00g, the total effective rate was 95.00 and the western group was 100.The total effective rate was 500.Results: The curative effect of Chinese and western group was higher than that of western group (P 0.01). Long term effect: the total effective rate of the Chinese and western groups was 94.30 and that of the western group was 35.3p 0.01. Compared with the normal control group, IL-8 TNF- 伪 IL-6 increased in both groups (P 0.01). After treatment, IL-8 in the Chinese and western groups was significantly lower than that in the control group (P 0.01) and TNF- 伪 IL-6 was lower than that before treatment (P 0.05). After treatment, IL-8 TNF- 伪 IL-6 in the western group was lower than that in the pre-treatment group (P 0.05). There was a significant difference between the two groups (P 0.01), TNF- 伪 and IL-6 (P 0.01) and TNF- 伪 (P 0.05). Conclusion: the clinical immunotherapy of oral lichen planus with traditional Chinese and western medicine has high curative effect, short course of treatment, low recurrence rate and no obvious side effects. It can improve the immune function of patients with oral lichen planus quickly and effectively, and is worthy of extensive clinical application.
【作者单位】：广西医科大学附属第九医院;广西北海市人民医院口腔科;
【分类号】：R781.59

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