中西医结合治疗晚期非小细胞肺癌临床优化方案研究

发布时间：2018-07-01 20:44

本文选题：中西医结合 + 扶正法　；参考：《中华中医药学刊》2015年11期

【摘要】：目的:观察中西医结合治疗晚期非小细胞肺癌(NSCLC)的临床疗效,以建立晚期非小细胞肺癌中西医结合临床优化治疗方案。方法:134例晚期NSCLC患者分为4组,正虚对照组(33例)、邪实对照组(33例)予顺铂(DDP)+多西紫杉醇(Doc)化疗;正虚观察组(34例)、邪实观察组(34例)在化疗基础上,正虚为主型予参芪扶正注射液和芪贞固本方;邪实为主型予苦参碱注射液和芩莲正积方。两周期后,比较两组患者治疗效果,观察1年,比较1年生存率。结果:与对照组相比,各观察组可明显提高肿瘤控制率、增加卡氏评分和体质量、降低症状积分和肿瘤标志物(CEA、CA19-9)、提高1年生存率、减轻消化道反应(P0.05);扶正观察组与其对照组相比可明显增强患者免疫功能,减轻骨髓抑制(P0.05)。结论:本研究所采用中西医结合治疗方案具有良好的治疗效果,能减毒增效,与单纯化疗相比有显著优势,值得临床广泛推广。
[Abstract]:Objective: to observe the clinical effect of combination of traditional Chinese and western medicine in the treatment of advanced non-small cell lung cancer (NSCLC), and to establish an optimized regimen of integrated traditional Chinese and western medicine for advanced non-small cell lung cancer (NSCLC). Methods one hundred and thirty-four patients with advanced NSCLC were divided into 4 groups: positive deficiency control group (33 cases), evil solid control group (33 cases) received DDP docetaxel (Doc) chemotherapy, positive deficiency observation group (34 cases) and evil solid observation group (34 cases) were treated with chemotherapy. Shenqi Fuzheng injection and Qizhen Guben prescription were given to the main type of deficiency, while Matrine injection and Qinlian Zhengji prescription were used as the main type of evil. After two cycles, the therapeutic effects, 1-year and 1-year survival rates were compared between the two groups. Results: compared with the control group, the control rate of tumor in each observation group was significantly increased, the Cardner score and body mass were increased, the symptom score and tumor marker (CEACA19-9) were decreased, and the 1-year survival rate was increased. Reduce digestive tract reaction (P0.05); Fuzheng observation group compared with its control group can significantly enhance the immune function of patients reduce bone marrow suppression (P0.05). Conclusion: the combination of traditional Chinese and western medicine has a good therapeutic effect, can reduce toxicity and increase efficiency, and has significant advantages compared with chemotherapy alone. It is worth popularizing in clinic.
【作者单位】：山东中医药大学附属医院;山东中医药大学;
【基金】：山东省中医药科技发展计划(2009Z003)
【分类号】：R734.2

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