中西医结合治疗高尿酸血症和痛风效果观察

发布时间：2018-07-14 10:02

【摘要】：目的:探讨中西医结合治疗高尿酸血症和痛风患者的效果。方法:选取2012年2月—2014年2月医院收治的高尿酸血症和痛风患者150例,按随机数字表法分为观察组和对照组,每组75例。对照组给予常规西医疗法,观察组在此基础上加用自拟四妙汤,每日1剂,疗程2个月。比较两组血尿酸、血沉、CRP、肾功能指标变化及不良反应,并评价临床疗效。结果:观察组总有效率为96.0%(72/75),显著高于对照组的84.0%(63/75),差异有统计学意义(χ2=4.26,P0.05)。两组治疗后UA、ESR、CRP均较治疗前显著降低(t=5.45、5.20、4.78、4.56、4.35、4.39,P0.05),两组比较观察组较对照组降低明显(t=4.11、4.02、4.55,P0.05)。两组治疗后血肌酐、尿素氮均较治疗前显著降低(t=5.45、5.20、4.78、4.56,P0.05),两组比较观察组较对照组降低明显(t=4.11、4.02,P0.05)。观察组不良反应发生率为2.7%(2/75),对照组为12.0%(9/75),差异有统计学意义(χ2=4.56,P0.05)。结论:相比西医常规疗法,中西医结合治疗高尿酸血症和痛风患者能显著提高疗效,能进一步降低血尿酸,消除炎症,改善肾功能,降低不良反应,值得临床推广应用。
[Abstract]:Objective: to investigate the effect of integrated traditional Chinese and western medicine on patients with hyperuricemia and gout. Methods: 150 patients with hyperuricemia and gout were selected from Feb 2012 to Feb 2014, and were divided into observation group (n = 75) and control group (n = 75). The control group was treated with routine western medicine, and the observation group was treated with self-made Simiao decoction once a day for 2 months. The changes of serum uric acid, erythrocyte sedimentation rate (ESR), renal function and adverse reactions were compared between the two groups. Results: the total effective rate of the observation group was 96.0% (72 / 75), which was significantly higher than that of the control group (84.0%) (63 / 75), and the difference was statistically significant (蠂 2 / 4.26 P 0.05). After treatment, the CRP of UAS in both groups was significantly lower than that before treatment (t = 5.45) (t _ (5.45) ~ (5.20) ~ (4.78) ~ (4.65) ~ (4.36) ~ (4.39) (P0.05), and it was significantly lower in the observation group than that in the control group (t _ (4.114.02) ~ (4.55). The levels of serum creatinine and urea nitrogen in the two groups were significantly lower than those before treatment (P 0.05), and those in the observation group were significantly lower than those in the control group (P 0.05). The incidence of adverse reactions was 2.7% (2 / 75) in the observation group and 12.0% (9 / 75) in the control group. The difference was statistically significant (蠂 24.56 P 0.05). Conclusion: compared with conventional western medicine, the treatment of hyperuricemia and gout with integrated traditional Chinese and western medicine can significantly improve the curative effect, further reduce blood uric acid, eliminate inflammation, improve renal function and reduce adverse reactions, which is worthy of clinical application.
【作者单位】： 杭州市第三医院内科;杭州绿城医院中医科;杭州市第二医院内科;
【分类号】：R589.7

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