中西医结合治疗小儿原发性肾病综合征随机对照试验的Meta分析
发布时间：2018-07-16 19:36
【摘要】：目的评价中西医结合治疗小儿原发性肾病综合征的疗效。方法计算机检索2000～2010年PubMed、Medline、中国生物医学文献光盘数据库(CBM disc)、中文期刊网全文数据库(CNKI)、中国优秀博硕士学位论文全文数据库(CDMD)、万方数据库、Cochrane Library(2010,第2期);并手工检索纳入文献的参考文献、相关学位论文和会议论文集。由2名研究人员分别独立检索、筛选文献,并独立对纳入文献依据Jadad量表进行质量评价和数据提取。用Rev-Man 5.1.5软件进行Meta分析。结果①共纳入17篇文献,980例患者,其中治疗组535例,对照组445例。除1篇Jadad评分3分的文献外,其余均为1～2分的低质量文献。各研究均明确指出基线均衡,具有可比性。有2篇文献提到使用随机数字表,其余文献只提到随机分组,但并未详细描述随机序列的产生方法。所有纳入文献均未对随机分配方案进行隐藏,均未使用盲法;②Meta分析结果显示:中西医结合疗法治疗小儿原发性肾病综合征在减少24h尿蛋白定量(UPT)(SMD-0.74,95%CI[-1.12,-0.37])、升高血浆白蛋白(ALB)(SMD 0.64,95%CI[0.38,0.90])、降低血脂(TC:MD-1.24,95%CI[-1.80,-0.69];TG:MD-0.41,95%CI[-0.66,-0.17])、减少复发率(RR 0.39,95%CI[0.30,0.52])和缩短水肿消退时间(MD-4.30,95%CI[-5.19,-3.41])方面优于常规激素或激素加免疫抑制剂治疗,且差异有统计学意义。结论在激素或激素加免疫抑制剂常规治疗的基础上加用中医药治疗,对小儿原发性肾病综合征患者24hUPT、血脂(TC、TG)、复发率的降低,水肿消退时间的缩短及升高ALB方面的作用优于常规治疗,且敏感性分析未能从实质上改变Meta分析的结果,但纳入该Meta分析的文献方法学质量较低,而且可能存在发表性偏倚,因此,尚有待于设计严密规范的大样本、多中心、随机双盲对照研究进一步证实。
[Abstract]:Objective to evaluate the effect of integrated traditional Chinese and western medicine on children with primary nephrotic syndrome. Methods computer search was conducted on PubMedine Medline from 2000 to 2010, full text Database of Chinese Biomedical Literature disc), (CNKI), full text Database of excellent Master's degree papers of China (CDMD), Cochrane Library of Wanfang (2010, 2nd issue), and manual examination. References included in the literature, Related dissertations and conference papers. The literature was searched and screened by two researchers, and the quality evaluation and data extraction based on Jadad scale were carried out independently. Meta-analysis was carried out with Rev-Man 5.1.5 software. Results 1 A total of 980 patients were included in 17 literatures, including 535 cases in the treatment group and 445 cases in the control group. Except for one piece of literature with Jadad score of 3, the rest were all of low quality literature with score of 1 ~ 2. Each study clearly points out that the baseline is balanced and comparable. There are two references to the use of random number tables and the rest to random grouping, but the method of generating random sequences is not described in detail. All the literature included did not hide the random distribution scheme, and no blind method was used. 鈶eta鍒嗘瀽缁撴灉鏄剧ず:涓タ鍖荤粨鍚堢枟娉曟不鐤楀皬鍎垮師鍙戞，
本文编号：2127454
[Abstract]:Objective to evaluate the effect of integrated traditional Chinese and western medicine on children with primary nephrotic syndrome. Methods computer search was conducted on PubMedine Medline from 2000 to 2010, full text Database of Chinese Biomedical Literature disc), (CNKI), full text Database of excellent Master's degree papers of China (CDMD), Cochrane Library of Wanfang (2010, 2nd issue), and manual examination. References included in the literature, Related dissertations and conference papers. The literature was searched and screened by two researchers, and the quality evaluation and data extraction based on Jadad scale were carried out independently. Meta-analysis was carried out with Rev-Man 5.1.5 software. Results 1 A total of 980 patients were included in 17 literatures, including 535 cases in the treatment group and 445 cases in the control group. Except for one piece of literature with Jadad score of 3, the rest were all of low quality literature with score of 1 ~ 2. Each study clearly points out that the baseline is balanced and comparable. There are two references to the use of random number tables and the rest to random grouping, but the method of generating random sequences is not described in detail. All the literature included did not hide the random distribution scheme, and no blind method was used. 鈶eta鍒嗘瀽缁撴灉鏄剧ず:涓タ鍖荤粨鍚堢枟娉曟不鐤楀皬鍎垮師鍙戞，
本文编号：2127454
本文链接：https://www.wllwen.com/yixuelunwen/zhxiyjh/2127454.html
